Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma

• Published in: The New England journal of medicine Vol. 368; no. 24; pp. 2266 - 2276
• Main Authors: Yong, Kol Jia, Gao, Chong, Lim, Joline S.J, Yan, Benedict, Yang, Henry, Dimitrov, Todor, Kawasaki, Akira, Ong, Chee Wee, Wong, Kwong-Fai, Lee, Sanghoon, Ravikumar, Sharada, Srivastava, Supriya, Tian, Xi, Poon, Ronnie T, Fan, Sheung Tat, Luk, John M, Dan, Yock Young, Salto-Tellez, Manuel, Chai, Li, Tenen, Daniel G
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 13.06.2013
• Subjects: Adult; Animals; Biological and medical sciences; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Cell survival; Fetuses; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression; Gene Expression Regulation, Neoplastic; General aspects; Hepatocellular carcinoma; Humans; Leukemia; Liver - metabolism; Liver cancer; Liver cirrhosis; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Medical research; Medical sciences; Metabolic Networks and Pathways - physiology; Metastases; Mice; Mice, Inbred Strains; Multiple tumors. Solid tumors. Tumors in childhood (general aspects); Patients; Phenotypes; Progenitor cells; Prognosis; PTEN Phosphohydrolase - metabolism; PTEN protein; Rodents; Statistical analysis; Stem cells; Tensin; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Transplantation, Heterologous; Tumor Cells, Cultured; Tumorigenicity; Tumors; Xenografts; Hong Kong China; China; Singapore; Medicine; Liver cancer; Gene; Digestive diseases; Hepatic disease; Hepatocellular carcinoma; Genetics; Malignant tumor; Cancer; High malignancy

SALL4, which is expressed in fetal but not adult liver, is reexpressed in a subgroup of hepatocellular cancers associated with a poor prognosis. In mice, treatment aimed at inhibiting SALL4 has antitumor effects. Hepatocellular carcinoma is the third leading cause of cancer-related deaths globally....