Prostate Cancer Theranostics - An Overview

Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a criti...

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Published inFrontiers in oncology Vol. 10; p. 884
Main Authors Abou, Diane, Benabdallah, Nadia, Jiang, Wen, Peng, Lu, Zhang, Hanwen, Villmer, Alexandria, Longtine, Mark S., Thorek, Daniel L. J.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 05.06.2020
Subjects
alpha particle
Oncology
peptide
prostate cancer
radionuclide
radiotherapy
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Summary:Metastatic prostate cancer is incurable, and novel methods to detect the disease earlier and to direct definitive treatment are needed. Molecularly specific tools to localize diagnostic and cytotoxic radionuclide payloads to cancer cells and the surrounding microenvironment are recognized as a critical component of new approaches to combat this disease. The implementation of theranostic approaches to characterize and personalize patient management is beginning to be realized for prostate cancer patients. This review article summarized clinically translated approaches to detect, characterize, and treat disease in this rapidly expanding field.
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This article was submitted to Cancer Imaging and Image-directed Interventions, a section of the journal Frontiers in Oncology
Edited by: Georgios S. Limouris, National and Kapodistrian University of Athens, Greece
Reviewed by: Di Dong, Institute of Automation (CAS), China; Caroline Rousseau, Institut de Cancérologie de l'Ouest (ICO), France
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.00884