Phenotype wide association study links bronchopulmonary dysplasia with eosinophilia in children

• Published in: Scientific reports Vol. 14; no. 1; pp. 21391 - 9
• Main Authors: Kelchtermans, Jelte, March, Michael E., Hakonarson, Hakon, McGrath-Morrow, Sharon A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.09.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/208/248; 631/208/2489; Asthma; Asthma - genetics; Blood levels; Bronchopulmonary Dysplasia - genetics; Bronchopulmonary Dysplasia - pathology; Child; Child, Preschool; Chronic obstructive pulmonary disease; DNA Methylation; DNA probes; Dysplasia; Eosinophilia; Eosinophilia - genetics; Epidemiology; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humanities and Social Sciences; Humans; Infant; Infant, Newborn; Inflammation; Interleukin-1 Receptor-Like 1 Protein - genetics; Leukocytes (eosinophilic); Lung diseases; Male; Methylation; multidisciplinary; Pediatrics; Phenotype; Phenotypes; Polymorphism, Single Nucleotide; Premature birth; Science; Science (multidisciplinary); Single-nucleotide polymorphism

Bronchopulmonary dysplasia (BPD) is a common complication of preterm birth. Despite this, genetic drivers of BPD are poorly understood. The objective of this study is to better understand the impact of single nucleotide polymorphisms (SNPs) previously associated with BPD by examining associations wi...