A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: Meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis

• Published in: Free radical biology & medicine Vol. 148; pp. 1 - 21
• Main Authors: Bialkowski, Karol, Kasprzak, Kazimierz S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 20.02.2020
• Subjects: Carcinogenesis; Cell Line, Tumor; DNA Repair Enzymes - genetics; Gene Expression; Humans; Phosphoric Monoester Hydrolases - genetics

We measured the specific 8-oxo-dGTPase activity profile of the NCI-60 panel of malignant cell lines, and MTH1 protein levels in a subset of 16 lines. Their 8-oxo-dGTPase activity was compared to twelve publicly accessible MTH1 mRNA expression data bases and their cross-consistency was analyzed. 8-ox...