Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer's Disease

• Published in: Journal of Alzheimer's disease Vol. 100; no. s1; p. S103
• Main Authors: Duits, Flora H, Nilsson, Johanna, Zetterberg, Henrik, Blennow, Kaj, van der Flier, Wiesje M, Teunissen, Charlotte E, Brinkmalm, Ann
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2024
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - diagnosis; Amyloid beta-Peptides - cerebrospinal fluid; Biomarkers - cerebrospinal fluid; C-Reactive Protein; Cognitive Dysfunction - cerebrospinal fluid; Cohort Studies; Disease Progression; Female; Humans; Male; Middle Aged; Nerve Tissue Proteins - cerebrospinal fluid; Neurofilament Proteins - cerebrospinal fluid; Synapses; Synaptosomal-Associated Protein 25 - cerebrospinal fluid; mass spectrometry; synapses; Alzheimer’s disease; cognitive decline; biomarkers

Synaptic dysfunction is closely associated with cognitive function in Alzheimer's disease (AD), and is present already in an early stage of the disease. Using serial cerebrospinal fluid (CSF) sampling, we aimed to investigate slopes of CSF synaptic proteins, and their relation with cognition al...