Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients
Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies individually. Here, we applied cytometry by time-of-flight (CyTOF) to establish the immune profile of peripheral blo...
Saved in:
Cover
Loading…
| Abstract | Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies individually. Here, we applied cytometry by time-of-flight (CyTOF) to establish the immune profile of peripheral blood mononuclear cells (PBMCs) on the single-cell level at indicated time points before, during, and after chemotherapy. Multiplex immunofluorescence staining was applied to examine the spatial distribution of certain immune clusters. Tissue microarrays (TMAs) were used for prognostic evaluation. A total of 20 ICC patients treated with gemcitabine (GEM) were enrolled in our study, including eight cases with good response (R) and 12 cases with non-response (NR). Tremendous changes in PBMC composition, including an increased level of CD4/CD8 double-positive T cells (DPT), were observed after chemotherapy. Patients with higher level of CD4+CD45RO+CXCR3+ T cells before treatment had a favorable response to chemotherapy. Our study identified a positive correlation between the percentage of T cell subpopulations and clinical response after chemotherapy, which suggests that it is practical to predict the potential response before treatment by evaluating the proportions of the cell population in PBMCs. |
|---|---|
| AbstractList | Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but chemosensitivity varies individually. Here, we applied cytometry by time-of-flight (CyTOF) to establish the immune profile of peripheral blood mononuclear cells (PBMCs) on the single-cell level at indicated time points before, during, and after chemotherapy. Multiplex immunofluorescence staining was applied to examine the spatial distribution of certain immune clusters. Tissue microarrays (TMAs) were used for prognostic evaluation. A total of 20 ICC patients treated with gemcitabine (GEM) were enrolled in our study, including eight cases with good response (R) and 12 cases with non-response (NR). Tremendous changes in PBMC composition, including an increased level of CD4/CD8 double-positive T cells (DPT), were observed after chemotherapy. Patients with higher level of CD4+CD45RO+CXCR3+ T cells before treatment had a favorable response to chemotherapy. Our study identified a positive correlation between the percentage of T cell subpopulations and clinical response after chemotherapy, which suggests that it is practical to predict the potential response before treatment by evaluating the proportions of the cell population in PBMCs. Intrahepatic cholangiocarcinoma(ICC)is the second most common liver cancer.Chemotherapy remains the main therapeutic strategy for advanced ICC patients,but chemosensitivity varies individually.Here,we applied cytometry by time-of-flight(CyTOF)to establish the immune profile of peripheral blood mononuclear cells(PBMCs)on the single-cell level at indicated time points before,during,and after chemotherapy.Multiplex immunofluorescence staining was applied to examine the spatial distribution of certain immune clusters.Tissue microarrays(TMAs)were used for prognostic evaluation.A total of 20 ICC patients treated with gemcitabine(GEM)were enrolled in our study,including eight cases with good response(R)and 12 cases with non-response(NR).Tremendous changes in PBMC composition,including an increased level of CD4/CD8 double-positive T cells(DPT),were observed after chemother-apy.Patients with higher level of CD4+CD45RO+CXCR3+T cells before treatment had a favorable response to chemotherapy.Our study identified a positive correlation between the percentage of T cell subpopu-lations and clinical response after chemotherapy,which suggests that it is practical to predict the poten-tial response before treatment by evaluating the proportions of the cell population in PBMCs. |
| Author | Yuan, Zhen-Gang Zheng, Bo Wu, Jian-Min Wang, Hong-Yang Sui, Cheng-Jun Chen, Lei Li, Wei Yang, Ying-Cheng Shen, Si-Yun Wang, Kai-Ting Ma, Wen-Cong Wu, Rui Li, Zhi-Xuan Wu, Tong Shi, Xue-Bing Zhao, Yan Wu, Xuan Wang, Shan Zhu, Yan-Jing |
| AuthorAffiliation | International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China;National Center for Liver Cancer,Shanghai 201805,China%Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Fudan University Shanghai Cancer Center,Shanghai 200032,China%Institute of Metabolism and Integrative Biology,Fudan University,Shanghai 200433,China%Department of Laboratory Medicine,The Tenth People's Hospital of Shanghai,Tongji University,Shanghai 200072,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surg |
| AuthorAffiliation_xml | – name: International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China;National Center for Liver Cancer,Shanghai 201805,China%Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Fudan University Shanghai Cancer Center,Shanghai 200032,China%Institute of Metabolism and Integrative Biology,Fudan University,Shanghai 200433,China%Department of Laboratory Medicine,The Tenth People's Hospital of Shanghai,Tongji University,Shanghai 200072,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China;Fudan University Shanghai Cancer Center,Shanghai 200032,China;Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education,Shanghai 200438,China%Department of Oncology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China |
| Author_xml | – sequence: 1 givenname: Tong surname: Wu fullname: Wu, Tong organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 2 givenname: Ying-Cheng surname: Yang fullname: Yang, Ying-Cheng organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 3 givenname: Bo surname: Zheng fullname: Zheng, Bo organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 4 givenname: Xue-Bing surname: Shi fullname: Shi, Xue-Bing organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 5 givenname: Wei surname: Li fullname: Li, Wei organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 6 givenname: Wen-Cong surname: Ma fullname: Ma, Wen-Cong organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 7 givenname: Shan surname: Wang fullname: Wang, Shan organization: Fudan University Shanghai Cancer Center, Shanghai 200032, China – sequence: 8 givenname: Zhi-Xuan surname: Li fullname: Li, Zhi-Xuan organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 9 givenname: Yan-Jing surname: Zhu fullname: Zhu, Yan-Jing organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 10 givenname: Jian-Min surname: Wu fullname: Wu, Jian-Min organization: Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200433, China – sequence: 11 givenname: Kai-Ting surname: Wang fullname: Wang, Kai-Ting organization: Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200433, China – sequence: 12 givenname: Yan surname: Zhao fullname: Zhao, Yan organization: Institute of Metabolism and Integrative Biology, Fudan University, Shanghai 200433, China – sequence: 13 givenname: Rui surname: Wu fullname: Wu, Rui organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 14 givenname: Cheng-Jun surname: Sui fullname: Sui, Cheng-Jun organization: Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 15 givenname: Si-Yun surname: Shen fullname: Shen, Si-Yun organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 16 givenname: Xuan surname: Wu fullname: Wu, Xuan organization: Department of Laboratory Medicine, The Tenth People’s Hospital of Shanghai, Tongji University, Shanghai 200072, China – sequence: 17 givenname: Lei surname: Chen fullname: Chen, Lei email: chenlei@smmu.edu.cn organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 18 givenname: Zhen-Gang surname: Yuan fullname: Yuan, Zhen-Gang email: yuanzg@163.com organization: Department of Oncology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China – sequence: 19 givenname: Hong-Yang surname: Wang fullname: Wang, Hong-Yang email: hywangk@vip.sina.com organization: International Cooperation Laboratory on Signal Transduction & Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer, Ministry of Education & Shanghai Key Laboratory of Hepatobiliary Tumor Biology, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China |
| BookMark | eNp9kUFr3DAQhXVIIWmaH9CbLz3uVpJt2aandtu0C4EuNDmLsTzyytjSImlT8u8z7pYeCwMC6b3Rm2_esisfPDL2XvCt4EJ9nLbox63kUmz5WtUVu5G8qzct77prdpfSxDkXteANb29Y-upSdt7kYr8sZ4_FLzd6yOeIqXC-OGB0pyNGmIsvcwhDcYg4OFLvjriEhD657J5dflnFe58jHPEE2RkShBn86IKBaJwPCxQHekCf0zv2xsKc8O7vecue7r897n5sHn5-3-8-P2xMVaq86ereStWBbNumsf2AfW2rFgCkrVQ3wGCNqaS1IHogGQipSppK1bK1gqMqb9n-0ncIMOlTdAvEFx3A6T8XIY4aImWdUdegmo6XJTZEzIqqK0tRVkqpZqha0XPq9eHS6zd4S3PpKZyjp_R6NBpX3IKwtqQTF52JIaWI9t-_gut1QXrStCC9OjRfqyLPp4sHCcazw6iTIVCGSEc0mdK6_7hfAY5QnPk |
| CitedBy_id | crossref_primary_10_1080_2162402X_2024_2371575 crossref_primary_10_1038_s41575_022_00741_4 crossref_primary_10_1016_j_bbcan_2023_188870 |
| Cites_doi | 10.1002/iub.2043 10.1038/s41416-019-0523-5 10.1016/S0140-6736(13)61903-0 10.1016/j.molimm.2019.02.014 10.1016/j.stem.2018.10.005 10.1002/advs.201802057 10.1007/s00262-019-02305-z 10.1146/annurev-immunol-032713-120145 10.1016/j.soc.2019.06.002 10.1016/j.ajpath.2017.09.013 10.1016/j.intimp.2019.105747 10.1016/j.jhep.2014.01.021 10.1016/j.biomaterials.2013.10.003 10.1002/cncr.32463 10.1007/s12072-019-09954-3 10.1002/cam4.2077 10.1186/s40880-019-0365-9 10.1136/gutjnl-2017-315485 10.21037/jgo.2019.05.10 10.1080/2162402X.2017.1386828 10.1021/acs.biomac.9b00707 10.1084/jem.184.3.963 10.1124/dmd.114.060798 10.1016/j.imlet.2016.11.009 10.1038/d41586-018-05214-w 10.1016/j.it.2012.02.010 10.1172/jci.insight.97828 10.1007/BF00194528 10.1016/j.leukres.2019.106188 10.1021/acschembio.7b00704 10.1016/j.eururo.2019.06.016 10.1038/s41525-018-0054-7 10.1186/s40425-018-0485-9 10.1016/j.carbpol.2019.115223 10.1097/SLA.0b013e318176c4d3 10.1002/advs.202000224 10.1016/j.jconrel.2019.07.014 10.1371/journal.pntd.0001294 10.1002/cam4.1984 10.1016/j.canlet.2019.05.017 10.1084/jem.178.3.1057 10.1016/j.ccell.2018.09.003 10.1158/0008-5472.CAN-04-2059 |
| ContentType | Journal Article |
| Copyright | 2021 Chinese Academy of Engineering Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| Copyright_xml | – notice: 2021 Chinese Academy of Engineering – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
| DBID | 6I. AAFTH AAYXX CITATION 2B. 4A8 92I 93N PSX TCJ DOA |
| DOI | 10.1016/j.eng.2021.01.014 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Wanfang Data Journals - Hong Kong WANFANG Data Centre Wanfang Data Journals 万方数据期刊 - 香港版 China Online Journals (COJ) China Online Journals (COJ) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Engineering |
| EndPage | 1392 |
| ExternalDocumentID | oai_doaj_org_article_5a679033e7014f149331346667d481b0 gc_e202110008 10_1016_j_eng_2021_01_014 S2095809921003209 |
| GroupedDBID | 0R~ 0SF 1-T 5VR 6I. 92H 92I 92R 93N AACTN AAEDW AAFTH AALRI AAXUO ABMAC ACGFS ACHIH ADBBV AEXQZ AFTJW AFUIB AITUG ALMA_UNASSIGNED_HOLDINGS AMRAJ BCNDV CCEZO CEKLB EBS EJD FDB GROUPED_DOAJ IPNFZ M41 NCXOZ O9- OK1 RIG ROL SSZ TCJ TGT -SC -S~ AAXDM AAYXX ADVLN AFJKZ AKRWK CAJEC CITATION Q-- U1G U5M 2B. 4A8 PSX |
| ID | FETCH-LOGICAL-c436t-95bf269a28877fbdeb5f48aaa2f469dadfcc42ffa1ba69aa12631076528f10e63 |
| IEDL.DBID | DOA |
| ISSN | 2095-8099 |
| IngestDate | Tue Oct 22 15:13:34 EDT 2024 Tue Feb 13 23:36:10 EST 2024 Thu Sep 26 18:20:54 EDT 2024 Thu Jul 20 20:12:43 EDT 2023 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 10 |
| Keywords | Chemosensitivity Peripheral blood mononuclear cells Gemcitabine Intrahepatic cholangiocarcinoma |
| Language | English |
| License | This is an open access article under the CC BY-NC-ND license. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c436t-95bf269a28877fbdeb5f48aaa2f469dadfcc42ffa1ba69aa12631076528f10e63 |
| OpenAccessLink | https://doaj.org/article/5a679033e7014f149331346667d481b0 |
| PageCount | 12 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_5a679033e7014f149331346667d481b0 wanfang_journals_gc_e202110008 crossref_primary_10_1016_j_eng_2021_01_014 elsevier_sciencedirect_doi_10_1016_j_eng_2021_01_014 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-10-01 |
| PublicationDateYYYYMMDD | 2021-10-01 |
| PublicationDate_xml | – month: 10 year: 2021 text: 2021-10-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationTitle | Engineering (Beijing, China) |
| PublicationTitle_FL | Engineering |
| PublicationYear | 2021 |
| Publisher | Elsevier Ltd National Center for Liver Cancer,Shanghai 201805,China%Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Fudan University Shanghai Cancer Center,Shanghai 200032,China%Institute of Metabolism and Integrative Biology,Fudan University,Shanghai 200433,China%Department of Laboratory Medicine,The Tenth People's Hospital of Shanghai,Tongji University,Shanghai 200072,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Fudan University Shanghai Cancer Center,Shanghai 200032,China Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education,Shanghai 200438,China%Department of Oncology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China Elsevier |
| Publisher_xml | – name: Elsevier Ltd – name: Fudan University Shanghai Cancer Center,Shanghai 200032,China – name: International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China – name: National Center for Liver Cancer,Shanghai 201805,China%Department of Hepatobiliary Surgery,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Fudan University Shanghai Cancer Center,Shanghai 200032,China%Institute of Metabolism and Integrative Biology,Fudan University,Shanghai 200433,China%Department of Laboratory Medicine,The Tenth People's Hospital of Shanghai,Tongji University,Shanghai 200072,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China – name: Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education,Shanghai 200438,China%Department of Oncology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China – name: Elsevier |
| References | Chen, Wu, Boyé, Pan, Chen, Pujol (b0175) 2017; 12 Endo, Gonen, Yopp, Dalal, Zhou, Klimstra (b0010) 2008; 248 Luster, Leder (b0185) 1993; 178 Razumilava, Gores (b0020) 2014; 383 Hanoteau, Newton, Krupar, Huang, Liu, Gaspero (b0095) 2019; 7 Givechian, Wnuk, Garner, Benz, Garban, Rabizadeh (b0065) 2018; 3 Chew, Lee, Pan, Nasir, Lim, Chua (b0025) 2019; 68 Giraldo, Bolaños, Cuellar, Guzman, Uribe, Bedoya (b0160) 2011; 5 Schneible, Singhal, Lilova, Hall, Grafmüller, Menegatti (b0140) 2019; 20 Tucci, Kheirolomoom, Ingham, Mahakian, Tam, Foiret (b0120) 2019; 309 Shewach, Lawrence (b0030) 1996; 14 Li, Wang, Deng, Wu, Huang, Sun (b0150) 2019; 6 El-Diwany, Pawlik, Ejaz (b0015) 2019; 28 Zhao, Zhu, Zhang, Han, Gao, Wei (b0145) 2017; 181 Bridgewater, Galle, Khan, Llovet, Park, Patel (b0005) 2014; 60 Cao, Ji, Zhang, Wang, Xu, Yu (b0090) 2019; 8 Bendall, Nolan, Roederer, Chattopadhyay (b0205) 2012; 33 Mu, Wang, Yao, Zheng, Jiang, Tan (b0050) 2019; 109 Medler, Murugan, Horton, Kumar, Cotechini, Forsyth (b0195) 2018; 34 Mullins, Slingluff, Lee, Garbee, Shu, Anderson (b0190) 2004; 64 Zhang, Xin, Chen, Gao (b0055) 2019; 71 Yan, Cao, Liu, Harrington, Bindeman, Adjei (b0075) 2018; 3 Kettunen, Boström, Lamminen, Heinosalo, West, Saarinen (b0125) 2019; 76 Wu, Wu, Wang, Chen (b0210) 2019; 39 Zeng, Xiao, Wang, Jiang, Shan, Hu (b0115) 2019; 75 Ouyang, Zhang, Xie, Ma (b0080) 2019; 18 Kim, Kawai, Wakisaka, Funaoka, Yasuda, Hidaka (b0155) 2019; 68 Griffith, Sokol, Luster (b0170) 2014; 32 Thomas, Vokali, Lund, Hubbell, Swartz (b0200) 2014; 35 Minagawa A, Yoshikawa T, Yasukawa M, Hotta A, Kunitomo M, et al. Enhancing T cell receptor stability in rejuvenated iPSC-derived T cells improves their use in cancer immunotherapy. Cell Stem Cell 2018;23(6):850–8.e4. Nezami, Camacho, Kokabi, El-Rayes, Kim (b0035) 2019; 10 Krupar, Hautmann, Pathak, Varier, McLaren, Gaag (b0105) 2018; 188 Zhang, Xu, Zhang, Chen, Wang, Zhu (b0085) 2019; 458 Loetscher, Gerber, Loetscher, Jones, Piali, Clark-Lewis (b0180) 1996; 184 Kostine, Briaire-de Bruijn, Cleven, Vervat, Corver, Schilham (b0100) 2018; 7 Lowery, Goff, Keenan, Jordan, Wang, Bocobo (b0040) 2019; 125 Zheng, Wang, Qiu, Luo, Wu, Yang (b0070) 2020; 7 Ganesan, Mehra, Joel, Radhakrishnan, Dhanushkodi, Perumal Kalayarasi (b0110) 2019; 84 Atkuri, Stevens, Neubert (b0220) 2015; 43 Ahn, O’Brien, Kang, Mounajjed, Kim, Kim (b0135) 2019; 13 Kim, Lee, Kim, Suh, Nam, Bang (b0130) 2019; 121 Xie, Ma, Zhou, Shen, Xu, Dou (b0045) 2019; 225 Duan, Wang, Liu, Huang, An, Pan (b0060) 2019; 8 Landhuis (b0215) 2018; 557 Mullins (10.1016/j.eng.2021.01.014_b0190) 2004; 64 El-Diwany (10.1016/j.eng.2021.01.014_b0015) 2019; 28 Kim (10.1016/j.eng.2021.01.014_b0155) 2019; 68 Chen (10.1016/j.eng.2021.01.014_b0175) 2017; 12 Zeng (10.1016/j.eng.2021.01.014_b0115) 2019; 75 Nezami (10.1016/j.eng.2021.01.014_b0035) 2019; 10 Schneible (10.1016/j.eng.2021.01.014_b0140) 2019; 20 Giraldo (10.1016/j.eng.2021.01.014_b0160) 2011; 5 Kettunen (10.1016/j.eng.2021.01.014_b0125) 2019; 76 10.1016/j.eng.2021.01.014_b0165 Zheng (10.1016/j.eng.2021.01.014_b0070) 2020; 7 Tucci (10.1016/j.eng.2021.01.014_b0120) 2019; 309 Xie (10.1016/j.eng.2021.01.014_b0045) 2019; 225 Ganesan (10.1016/j.eng.2021.01.014_b0110) 2019; 84 Zhao (10.1016/j.eng.2021.01.014_b0145) 2017; 181 Ouyang (10.1016/j.eng.2021.01.014_b0080) 2019; 18 Medler (10.1016/j.eng.2021.01.014_b0195) 2018; 34 Duan (10.1016/j.eng.2021.01.014_b0060) 2019; 8 Li (10.1016/j.eng.2021.01.014_b0150) 2019; 6 Mu (10.1016/j.eng.2021.01.014_b0050) 2019; 109 Cao (10.1016/j.eng.2021.01.014_b0090) 2019; 8 Razumilava (10.1016/j.eng.2021.01.014_b0020) 2014; 383 Landhuis (10.1016/j.eng.2021.01.014_b0215) 2018; 557 Endo (10.1016/j.eng.2021.01.014_b0010) 2008; 248 Zhang (10.1016/j.eng.2021.01.014_b0055) 2019; 71 Krupar (10.1016/j.eng.2021.01.014_b0105) 2018; 188 Kim (10.1016/j.eng.2021.01.014_b0130) 2019; 121 Bendall (10.1016/j.eng.2021.01.014_b0205) 2012; 33 Chew (10.1016/j.eng.2021.01.014_b0025) 2019; 68 Kostine (10.1016/j.eng.2021.01.014_b0100) 2018; 7 Givechian (10.1016/j.eng.2021.01.014_b0065) 2018; 3 Griffith (10.1016/j.eng.2021.01.014_b0170) 2014; 32 Atkuri (10.1016/j.eng.2021.01.014_b0220) 2015; 43 Lowery (10.1016/j.eng.2021.01.014_b0040) 2019; 125 Hanoteau (10.1016/j.eng.2021.01.014_b0095) 2019; 7 Loetscher (10.1016/j.eng.2021.01.014_b0180) 1996; 184 Luster (10.1016/j.eng.2021.01.014_b0185) 1993; 178 Yan (10.1016/j.eng.2021.01.014_b0075) 2018; 3 Bridgewater (10.1016/j.eng.2021.01.014_b0005) 2014; 60 Shewach (10.1016/j.eng.2021.01.014_b0030) 1996; 14 Ahn (10.1016/j.eng.2021.01.014_b0135) 2019; 13 Wu (10.1016/j.eng.2021.01.014_b0210) 2019; 39 Zhang (10.1016/j.eng.2021.01.014_b0085) 2019; 458 Thomas (10.1016/j.eng.2021.01.014_b0200) 2014; 35 |
| References_xml | – volume: 84 start-page: 106188 year: 2019 ident: b0110 article-title: Gemcitabine, vinorelbine and dexamethasone: a safe and effective regimen for treatment of relapsed/refractory Hodgkin’s lymphoma publication-title: Leuk Res contributor: fullname: Perumal Kalayarasi – volume: 121 start-page: 332 year: 2019 end-page: 339 ident: b0130 article-title: Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study publication-title: Br J Cancer contributor: fullname: Bang – volume: 184 start-page: 963 year: 1996 end-page: 969 ident: b0180 article-title: Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activated T-lymphocytes publication-title: J Exp Med contributor: fullname: Clark-Lewis – volume: 28 start-page: 587 year: 2019 end-page: 599 ident: b0015 article-title: Intrahepatic cholangiocarcinoma publication-title: Surg Oncol Clin N Am contributor: fullname: Ejaz – volume: 7 start-page: 10 year: 2019 ident: b0095 article-title: Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy publication-title: J Immunother Cancer contributor: fullname: Gaspero – volume: 181 start-page: 36 year: 2017 end-page: 44 ident: b0145 article-title: Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4 publication-title: Immunol Lett contributor: fullname: Wei – volume: 225 year: 2019 ident: b0045 article-title: Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4/MAPKs/NF-κB pathway publication-title: Carbohydr Polym contributor: fullname: Dou – volume: 7 start-page: 2000224 year: 2020 ident: b0070 article-title: Trajectory and functional analysis of PD-1(high) CD4 publication-title: Adv Sci contributor: fullname: Yang – volume: 39 start-page: 21 year: 2019 ident: b0210 article-title: Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer publication-title: Cancer Commun contributor: fullname: Chen – volume: 3 start-page: 14 year: 2018 ident: b0065 article-title: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples publication-title: NPJ Genom Med contributor: fullname: Rabizadeh – volume: 18 start-page: 2547 year: 2019 end-page: 2553 ident: b0080 article-title: Long noncoding RNA MAFG-AS1 promotes proliferation, migration and invasion of hepatocellular carcinoma cells through downregulation of miR-6852 publication-title: Exp Ther Med contributor: fullname: Ma – volume: 458 start-page: 123 year: 2019 end-page: 135 ident: b0085 article-title: Targeting the tumour immune microenvironment for cancer therapy in human gastrointestinal malignancies publication-title: Cancer Lett contributor: fullname: Zhu – volume: 64 start-page: 7697 year: 2004 end-page: 7701 ident: b0190 article-title: CXC chemokine receptor 3 expression by activated CD8 publication-title: Cancer Res contributor: fullname: Anderson – volume: 43 start-page: 227 year: 2015 end-page: 233 ident: b0220 article-title: Mass cytometry: a highly multiplexed single-cell technology for advancing drug development publication-title: Drug Metab Dispos contributor: fullname: Neubert – volume: 12 start-page: 2767 year: 2017 end-page: 2778 ident: b0175 article-title: Oligomerization state of CXCL4 chemokines regulates G protein-coupled receptor activation publication-title: ACS Chem Biol contributor: fullname: Pujol – volume: 10 start-page: 944 year: 2019 end-page: 956 ident: b0035 article-title: Phase Ib trial of gemcitabine with yttrium-90 in patients with hepatic metastasis of pancreatobiliary origin publication-title: J Gastrointest Oncol contributor: fullname: Kim – volume: 557 start-page: 595 year: 2018 end-page: 597 ident: b0215 article-title: Single-cell approaches to immune profiling publication-title: Nature contributor: fullname: Landhuis – volume: 7 year: 2018 ident: b0100 article-title: Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies publication-title: OncoImmunology contributor: fullname: Schilham – volume: 125 start-page: 4426 year: 2019 end-page: 4434 ident: b0040 article-title: Second-line chemotherapy in advanced biliary cancers: a retrospective, multicenter analysis of outcomes publication-title: Cancer contributor: fullname: Bocobo – volume: 34 start-page: 561 year: 2018 end-page: 578.e6 ident: b0195 article-title: Complement C5a fosters squamous carcinogenesis and limits T cell response to chemotherapy publication-title: Cancer Cell contributor: fullname: Forsyth – volume: 248 start-page: 84 year: 2008 end-page: 96 ident: b0010 article-title: Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection publication-title: Ann Surg contributor: fullname: Klimstra – volume: 383 start-page: 2168 year: 2014 end-page: 2179 ident: b0020 article-title: Cholangiocarcinoma publication-title: Lancet contributor: fullname: Gores – volume: 13 start-page: 490 year: 2019 end-page: 500 ident: b0135 article-title: Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach publication-title: Hepatol Int contributor: fullname: Kim – volume: 75 start-page: 105747 year: 2019 ident: b0115 article-title: Clinical efficacy and safety of synthetic thymic peptides with chemotherapy for non-small cell lung cancer in China: a systematic review and meta-analysis of 27 randomized controlled trials following the PRISMA guidelines publication-title: Int Immunopharmacol contributor: fullname: Hu – volume: 35 start-page: 814 year: 2014 end-page: 824 ident: b0200 article-title: Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response publication-title: Biomaterials contributor: fullname: Swartz – volume: 5 year: 2011 ident: b0160 article-title: Increased CD4 publication-title: PLoS Negl Trop Dis contributor: fullname: Bedoya – volume: 71 start-page: 986 year: 2019 end-page: 991 ident: b0055 article-title: Chemoresistance in mesenchymal lung cancer cells is correlated to high regulatory T cell presence in the tumor microenvironment publication-title: IUBMB Life contributor: fullname: Gao – volume: 8 start-page: 1004 year: 2019 end-page: 1012 ident: b0090 article-title: The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy publication-title: Cancer Med contributor: fullname: Yu – volume: 76 start-page: 430 year: 2019 end-page: 434 ident: b0125 article-title: Personalized drug sensitivity screening for bladder cancer using conditionally reprogrammed patient-derived cells publication-title: Eur Urol contributor: fullname: Saarinen – volume: 8 start-page: 2675 year: 2019 end-page: 2685 ident: b0060 article-title: Novel immune-risk score of gastric cancer: a molecular prediction model combining the value of immune-risk status and chemosensitivity publication-title: Cancer Med contributor: fullname: Pan – volume: 178 start-page: 1057 year: 1993 end-page: 1065 ident: b0185 article-title: IP-10, a-CXC-chemokine, elicits a potent thymus-dependent antitumor response publication-title: J Exp Med contributor: fullname: Leder – volume: 188 start-page: 72 year: 2018 end-page: 83 ident: b0105 article-title: Immunometabolic determinants of chemoradiotherapy response and survival in head and neck squamous cell carcinoma publication-title: Am J Pathol contributor: fullname: Gaag – volume: 3 year: 2018 ident: b0075 article-title: CX3CR1 identifies PD-1 therapy-responsive CD8 publication-title: JCI Insight contributor: fullname: Adjei – volume: 33 start-page: 323 year: 2012 end-page: 332 ident: b0205 article-title: A deep profiler’s guide to cytometry publication-title: Trends Immunol contributor: fullname: Chattopadhyay – volume: 109 start-page: 140 year: 2019 end-page: 148 ident: b0050 article-title: RS 504393 inhibits M-MDSCs recruiting in immune microenvironment of bladder cancer after gemcitabine treatment publication-title: Mol Immunol contributor: fullname: Tan – volume: 309 start-page: 277 year: 2019 end-page: 288 ident: b0120 article-title: Tumor-specific delivery of gemcitabine with activatable liposomes publication-title: J Control Release contributor: fullname: Foiret – volume: 68 start-page: 335 year: 2019 end-page: 346 ident: b0025 article-title: Immune activation underlies a sustained clinical response to yttrium-90 radioembolisation in hepatocellular carcinoma publication-title: Gut contributor: fullname: Chua – volume: 68 start-page: 577 year: 2019 end-page: 585 ident: b0155 article-title: A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients publication-title: Cancer Immunol Immunother contributor: fullname: Hidaka – volume: 32 start-page: 659 year: 2014 end-page: 702 ident: b0170 article-title: Chemokines and chemokine receptors: positioning cells for host defense and immunity publication-title: Annu Rev Immunol contributor: fullname: Luster – volume: 60 start-page: 1268 year: 2014 end-page: 1289 ident: b0005 article-title: Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma publication-title: J Hepatol contributor: fullname: Patel – volume: 14 start-page: 257 year: 1996 end-page: 263 ident: b0030 article-title: Gemcitabine and radiosensitization in human tumor cells publication-title: Invest New Drugs contributor: fullname: Lawrence – volume: 6 start-page: 1802057 year: 2019 ident: b0150 article-title: Robust photodynamic therapy using 5-ALA-incorporated nanocomplexes cures metastatic melanoma through priming of CD4 publication-title: Adv Sci contributor: fullname: Sun – volume: 20 start-page: 3126 year: 2019 end-page: 3141 ident: b0140 article-title: Tailoring the chemical modification of chitosan hydrogels to fine tune the release of a synergistic combination of chemotherapeutics publication-title: Biomacromolecules contributor: fullname: Menegatti – volume: 71 start-page: 986 issue: 7 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0055 article-title: Chemoresistance in mesenchymal lung cancer cells is correlated to high regulatory T cell presence in the tumor microenvironment publication-title: IUBMB Life doi: 10.1002/iub.2043 contributor: fullname: Zhang – volume: 121 start-page: 332 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0130 article-title: Enhanced antitumor effect of binimetinib in combination with capecitabine for biliary tract cancer patients with mutations in the RAS/RAF/MEK/ERK pathway: phase Ib study publication-title: Br J Cancer doi: 10.1038/s41416-019-0523-5 contributor: fullname: Kim – volume: 383 start-page: 2168 issue: 9935 year: 2014 ident: 10.1016/j.eng.2021.01.014_b0020 article-title: Cholangiocarcinoma publication-title: Lancet doi: 10.1016/S0140-6736(13)61903-0 contributor: fullname: Razumilava – volume: 109 start-page: 140 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0050 article-title: RS 504393 inhibits M-MDSCs recruiting in immune microenvironment of bladder cancer after gemcitabine treatment publication-title: Mol Immunol doi: 10.1016/j.molimm.2019.02.014 contributor: fullname: Mu – ident: 10.1016/j.eng.2021.01.014_b0165 doi: 10.1016/j.stem.2018.10.005 – volume: 6 start-page: 1802057 issue: 5 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0150 article-title: Robust photodynamic therapy using 5-ALA-incorporated nanocomplexes cures metastatic melanoma through priming of CD4+CD8+ double positive T cells publication-title: Adv Sci doi: 10.1002/advs.201802057 contributor: fullname: Li – volume: 68 start-page: 577 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0155 article-title: A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients publication-title: Cancer Immunol Immunother doi: 10.1007/s00262-019-02305-z contributor: fullname: Kim – volume: 32 start-page: 659 issue: 1 year: 2014 ident: 10.1016/j.eng.2021.01.014_b0170 article-title: Chemokines and chemokine receptors: positioning cells for host defense and immunity publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-032713-120145 contributor: fullname: Griffith – volume: 28 start-page: 587 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0015 article-title: Intrahepatic cholangiocarcinoma publication-title: Surg Oncol Clin N Am doi: 10.1016/j.soc.2019.06.002 contributor: fullname: El-Diwany – volume: 188 start-page: 72 issue: 1 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0105 article-title: Immunometabolic determinants of chemoradiotherapy response and survival in head and neck squamous cell carcinoma publication-title: Am J Pathol doi: 10.1016/j.ajpath.2017.09.013 contributor: fullname: Krupar – volume: 75 start-page: 105747 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0115 article-title: Clinical efficacy and safety of synthetic thymic peptides with chemotherapy for non-small cell lung cancer in China: a systematic review and meta-analysis of 27 randomized controlled trials following the PRISMA guidelines publication-title: Int Immunopharmacol doi: 10.1016/j.intimp.2019.105747 contributor: fullname: Zeng – volume: 60 start-page: 1268 issue: 6 year: 2014 ident: 10.1016/j.eng.2021.01.014_b0005 article-title: Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma publication-title: J Hepatol doi: 10.1016/j.jhep.2014.01.021 contributor: fullname: Bridgewater – volume: 35 start-page: 814 issue: 2 year: 2014 ident: 10.1016/j.eng.2021.01.014_b0200 article-title: Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response publication-title: Biomaterials doi: 10.1016/j.biomaterials.2013.10.003 contributor: fullname: Thomas – volume: 125 start-page: 4426 issue: 24 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0040 article-title: Second-line chemotherapy in advanced biliary cancers: a retrospective, multicenter analysis of outcomes publication-title: Cancer doi: 10.1002/cncr.32463 contributor: fullname: Lowery – volume: 13 start-page: 490 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0135 article-title: Prognostic subclass of intrahepatic cholangiocarcinoma by integrative molecular-clinical analysis and potential targeted approach publication-title: Hepatol Int doi: 10.1007/s12072-019-09954-3 contributor: fullname: Ahn – volume: 8 start-page: 2675 issue: 5 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0060 article-title: Novel immune-risk score of gastric cancer: a molecular prediction model combining the value of immune-risk status and chemosensitivity publication-title: Cancer Med doi: 10.1002/cam4.2077 contributor: fullname: Duan – volume: 39 start-page: 21 issue: 1 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0210 article-title: Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer publication-title: Cancer Commun doi: 10.1186/s40880-019-0365-9 contributor: fullname: Wu – volume: 68 start-page: 335 issue: 2 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0025 article-title: Immune activation underlies a sustained clinical response to yttrium-90 radioembolisation in hepatocellular carcinoma publication-title: Gut doi: 10.1136/gutjnl-2017-315485 contributor: fullname: Chew – volume: 10 start-page: 944 issue: 5 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0035 article-title: Phase Ib trial of gemcitabine with yttrium-90 in patients with hepatic metastasis of pancreatobiliary origin publication-title: J Gastrointest Oncol doi: 10.21037/jgo.2019.05.10 contributor: fullname: Nezami – volume: 7 issue: 2 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0100 article-title: Increased infiltration of M2-macrophages, T-cells and PD-L1 expression in high grade leiomyosarcomas supports immunotherapeutic strategies publication-title: OncoImmunology doi: 10.1080/2162402X.2017.1386828 contributor: fullname: Kostine – volume: 20 start-page: 3126 issue: 8 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0140 article-title: Tailoring the chemical modification of chitosan hydrogels to fine tune the release of a synergistic combination of chemotherapeutics publication-title: Biomacromolecules doi: 10.1021/acs.biomac.9b00707 contributor: fullname: Schneible – volume: 184 start-page: 963 issue: 3 year: 1996 ident: 10.1016/j.eng.2021.01.014_b0180 article-title: Chemokine receptor specific for IP10 and Mig: structure, function, and expression in activated T-lymphocytes publication-title: J Exp Med doi: 10.1084/jem.184.3.963 contributor: fullname: Loetscher – volume: 43 start-page: 227 issue: 2 year: 2015 ident: 10.1016/j.eng.2021.01.014_b0220 article-title: Mass cytometry: a highly multiplexed single-cell technology for advancing drug development publication-title: Drug Metab Dispos doi: 10.1124/dmd.114.060798 contributor: fullname: Atkuri – volume: 181 start-page: 36 year: 2017 ident: 10.1016/j.eng.2021.01.014_b0145 article-title: Gemcitabine treatment enhanced the anti-tumor effect of cytokine induced killer cells by depletion of CD4+CD25bri regulatory T cells publication-title: Immunol Lett doi: 10.1016/j.imlet.2016.11.009 contributor: fullname: Zhao – volume: 557 start-page: 595 issue: 7706 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0215 article-title: Single-cell approaches to immune profiling publication-title: Nature doi: 10.1038/d41586-018-05214-w contributor: fullname: Landhuis – volume: 33 start-page: 323 issue: 7 year: 2012 ident: 10.1016/j.eng.2021.01.014_b0205 article-title: A deep profiler’s guide to cytometry publication-title: Trends Immunol doi: 10.1016/j.it.2012.02.010 contributor: fullname: Bendall – volume: 3 issue: 8 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0075 article-title: CX3CR1 identifies PD-1 therapy-responsive CD8+ T cells that withstand chemotherapy during cancer chemoimmunotherapy publication-title: JCI Insight doi: 10.1172/jci.insight.97828 contributor: fullname: Yan – volume: 14 start-page: 257 issue: 3 year: 1996 ident: 10.1016/j.eng.2021.01.014_b0030 article-title: Gemcitabine and radiosensitization in human tumor cells publication-title: Invest New Drugs doi: 10.1007/BF00194528 contributor: fullname: Shewach – volume: 84 start-page: 106188 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0110 article-title: Gemcitabine, vinorelbine and dexamethasone: a safe and effective regimen for treatment of relapsed/refractory Hodgkin’s lymphoma publication-title: Leuk Res doi: 10.1016/j.leukres.2019.106188 contributor: fullname: Ganesan – volume: 12 start-page: 2767 issue: 11 year: 2017 ident: 10.1016/j.eng.2021.01.014_b0175 article-title: Oligomerization state of CXCL4 chemokines regulates G protein-coupled receptor activation publication-title: ACS Chem Biol doi: 10.1021/acschembio.7b00704 contributor: fullname: Chen – volume: 76 start-page: 430 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0125 article-title: Personalized drug sensitivity screening for bladder cancer using conditionally reprogrammed patient-derived cells publication-title: Eur Urol doi: 10.1016/j.eururo.2019.06.016 contributor: fullname: Kettunen – volume: 3 start-page: 14 issue: 1 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0065 article-title: Identification of an immune gene expression signature associated with favorable clinical features in Treg-enriched patient tumor samples publication-title: NPJ Genom Med doi: 10.1038/s41525-018-0054-7 contributor: fullname: Givechian – volume: 7 start-page: 10 issue: 1 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0095 article-title: Tumor microenvironment modulation enhances immunologic benefit of chemoradiotherapy publication-title: J Immunother Cancer doi: 10.1186/s40425-018-0485-9 contributor: fullname: Hanoteau – volume: 225 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0045 article-title: Polysaccharide enhanced NK cell cytotoxicity against pancreatic cancer via TLR4/MAPKs/NF-κB pathway in vitro/vivo publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2019.115223 contributor: fullname: Xie – volume: 18 start-page: 2547 issue: 4 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0080 article-title: Long noncoding RNA MAFG-AS1 promotes proliferation, migration and invasion of hepatocellular carcinoma cells through downregulation of miR-6852 publication-title: Exp Ther Med contributor: fullname: Ouyang – volume: 248 start-page: 84 issue: 1 year: 2008 ident: 10.1016/j.eng.2021.01.014_b0010 article-title: Intrahepatic cholangiocarcinoma: rising frequency, improved survival, and determinants of outcome after resection publication-title: Ann Surg doi: 10.1097/SLA.0b013e318176c4d3 contributor: fullname: Endo – volume: 7 start-page: 2000224 issue: 13 year: 2020 ident: 10.1016/j.eng.2021.01.014_b0070 article-title: Trajectory and functional analysis of PD-1(high) CD4+CD8+ T cells in hepatocellular carcinoma by single-cell cytometry and transcriptome sequencing publication-title: Adv Sci doi: 10.1002/advs.202000224 contributor: fullname: Zheng – volume: 309 start-page: 277 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0120 article-title: Tumor-specific delivery of gemcitabine with activatable liposomes publication-title: J Control Release doi: 10.1016/j.jconrel.2019.07.014 contributor: fullname: Tucci – volume: 5 year: 2011 ident: 10.1016/j.eng.2021.01.014_b0160 article-title: Increased CD4+/CD8+ double-positive T cells in chronic chagasic patients publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0001294 contributor: fullname: Giraldo – volume: 8 start-page: 1004 issue: 3 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0090 article-title: The preoperative neutrophil-to-lymphocyte ratio is not a marker of prostate cancer characteristics but is an independent predictor of biochemical recurrence in patients receiving radical prostatectomy publication-title: Cancer Med doi: 10.1002/cam4.1984 contributor: fullname: Cao – volume: 458 start-page: 123 year: 2019 ident: 10.1016/j.eng.2021.01.014_b0085 article-title: Targeting the tumour immune microenvironment for cancer therapy in human gastrointestinal malignancies publication-title: Cancer Lett doi: 10.1016/j.canlet.2019.05.017 contributor: fullname: Zhang – volume: 178 start-page: 1057 issue: 3 year: 1993 ident: 10.1016/j.eng.2021.01.014_b0185 article-title: IP-10, a-CXC-chemokine, elicits a potent thymus-dependent antitumor response in vivo publication-title: J Exp Med doi: 10.1084/jem.178.3.1057 contributor: fullname: Luster – volume: 34 start-page: 561 issue: 4 year: 2018 ident: 10.1016/j.eng.2021.01.014_b0195 article-title: Complement C5a fosters squamous carcinogenesis and limits T cell response to chemotherapy publication-title: Cancer Cell doi: 10.1016/j.ccell.2018.09.003 contributor: fullname: Medler – volume: 64 start-page: 7697 issue: 21 year: 2004 ident: 10.1016/j.eng.2021.01.014_b0190 article-title: CXC chemokine receptor 3 expression by activated CD8+ T cells is associated with survival in melanoma patients with stage III disease publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-04-2059 contributor: fullname: Mullins |
| SSID | ssj0001510708 |
| Score | 2.2528062 |
| Snippet | Intrahepatic cholangiocarcinoma (ICC) is the second most common liver cancer. Chemotherapy remains the main therapeutic strategy for advanced ICC patients, but... Intrahepatic cholangiocarcinoma(ICC)is the second most common liver cancer.Chemotherapy remains the main therapeutic strategy for advanced ICC patients,but... |
| SourceID | doaj wanfang crossref elsevier |
| SourceType | Open Website Aggregation Database Publisher |
| StartPage | 1381 |
| SubjectTerms | Chemosensitivity Gemcitabine Intrahepatic cholangiocarcinoma Peripheral blood mononuclear cells |
| Title | Distinct Immune Signatures in Peripheral Blood Predict Chemosensitivity in Intrahepatic Cholangiocarcinoma Patients |
| URI | https://dx.doi.org/10.1016/j.eng.2021.01.014 https://d.wanfangdata.com.cn/periodical/gc-e202110008 https://doaj.org/article/5a679033e7014f149331346667d481b0 |
| Volume | 7 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYlEGgPoU-6bRp06KlgYlmyZB-zbUNSaFloArkJPV2XRBvWLvn7nbG8ZXNJLgWfzCCJ0UjzjTT6hpCPPLRlcB7J8IwqhFCmMOD2CulKYTiDbdlgoPj9hzy7FN-u6qudUl-YE5bpgbPijmsjVVtyHhSA-Qh4nnPGBYBu5QVArhyts3onmMrvgyGsyeXoAEPANty22yvNKbkrpA5iw4pNlJ1M3HNKE3f_Pd-0f2dSNKnb8Tynz8nBDBnpSR7qC_IkpJfk2Q6R4CsyfMGlmtxIz_G9R6A_-y5Tdg60T3QFYhN9wDVdYqI6XW3wfmakSBewHjCHPReRQOFzPO79FTDT2oHAGk80e_B4G9en9Y2hq8zEOrwml6dfLz6fFXM5hcIJLseirW2sZGsq2FdUtD7YOorGGFNFiJG98dE5UcVomDUgZlglAfspWVdNZGWQ_A3ZS-sU3hIamCyt8I1TjRDWKsuYj5I5b1lo2sovyKetPvVtZs3Q23Sy37AeO43K1yV-YkGWqPF_gkh4Pf0AM9CzGejHzGBBxHa-9IwdMiaApvqH-j6a51bPa3fQndMBRfDmo3n3Pwb3njzFBnMO4CHZGzd_wgfAMqM9msz2L2dS7d8 |
| link.rule.ids | 315,786,790,870,2115,27955,27956 |
| linkProvider | Directory of Open Access Journals |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Distinct+Immune+Signatures+in+Peripheral+Blood+Predict+Chemosensitivity+in+Intrahepatic+Cholangiocarcinoma+Patients&rft.jtitle=%E5%B7%A5%E7%A8%8B%EF%BC%88%E8%8B%B1%E6%96%87%EF%BC%89&rft.au=Tong+Wu&rft.au=Ying-Cheng+Yang&rft.au=Bo+Zheng&rft.au=Xue-Bing+Shi&rft.date=2021-10-01&rft.pub=National+Center+for+Liver+Cancer%2CShanghai+201805%2CChina%25Department+of+Hepatobiliary+Surgery%2CEastern+Hepatobiliary+Surgery+Hospital%2CSecond+Military+Medical+University%2CShanghai+200438%2CChina%25Fudan+University+Shanghai+Cancer+Center%2CShanghai+200032%2CChina%25Institute+of+Metabolism+and+Integrative+Biology%2CFudan+University%2CShanghai+200433%2CChina%25Department+of+Laboratory+Medicine%2CThe+Tenth+People%27s+Hospital+of+Shanghai%2CTongji+University%2CShanghai+200072%2CChina%25International+Cooperation+Laboratory+on+Signal+Transduction%26Key+Laboratory+of+Signaling+Regulation+and+Targeting+Therapy+of+Liver+Cancer%2CMinistry+of+Education%26Shanghai+Key+Laboratory+of+Hepatobiliary+Tumor+Biology%2CEastern+Hepatobiliary+Surgery+Hospital%2CSecond+Military+Medical+University%2CShanghai+200438%2CChina&rft.issn=2095-8099&rft.volume=7&rft.issue=10&rft.spage=1381&rft.epage=1392&rft_id=info:doi/10.1016%2Fj.eng.2021.01.014&rft.externalDocID=gc_e202110008 |
| thumbnail_s | http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fgc-e%2Fgc-e.jpg |