Familial clustering of dysbiotic oral and fecal microbiomes in juvenile dermatomyositis

• Published in: Scientific reports Vol. 14; no. 1; pp. 16158 - 13
• Main Authors: Koester, Sean T., Chow, Albert, Pepper-Tunick, Evan, Lee, Peggy, Eckert, Mary, Brenchley, Laurie, Gardner, Pamela, Song, Hyun Jung, Li, Naisi, Schiffenbauer, Adam, Volochayev, Rita, Bayat, Nastaran, McLean, Jeffrey S., Rider, Lisa G., Shenoi, Susan, Stevens, Anne M., Dey, Neelendu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 12.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/326/2565/2134; 692/4023/1670/427; Adolescent; Adult; Child; Child, Preschool; Children; Community structure; Dermatomyositis; Dermatomyositis - genetics; Dermatomyositis - microbiology; Dysbiosis - microbiology; Families & family life; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome - genetics; Humanities and Social Sciences; Humans; Immunomodulation; Intestinal microflora; Male; Microbiomes; Microbiota - genetics; Mouth - microbiology; multidisciplinary; Observational studies; Oral cavity; Prospective Studies; RNA, Ribosomal, 16S - genetics; rRNA 16S; Saliva; Saliva - microbiology; Science; Science (multidisciplinary); Siblings

Juvenile dermatomyositis (JDM) is a rare immune-mediated disease of childhood with putative links to microbial exposures. In this multi-center, prospective, observational cohort study, we evaluated whether JDM is associated with discrete oral and gut microbiome signatures. We generated 16S rRNA sequ...