Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease?

• Published in: Ageing research reviews Vol. 13; pp. 107 - 114
• Main Authors: Bisaglia, Marco, Filograna, Roberta, Beltramini, Mariano, Bubacco, Luigi
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.01.2014; Elsevier
• Subjects: Animals; Biological and medical sciences; Brain - metabolism; Brain - pathology; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Development. Metamorphosis. Moult. Ageing; Disease Progression; Dopamine; Dopamine - analogs & derivatives; Dopamine - metabolism; Dopamine-quinones; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Fundamental and applied biological sciences. Psychology; Humans; Internal Medicine; Medical sciences; Mitochondria; Mitochondria - metabolism; Nerve Degeneration; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; Oxidation-Reduction; Oxidative Stress; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Signal Transduction; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Oxidative stress; Mitochondria; Dopamine; Parkinson's disease; Dopamine-quinones; Sporadic; Pathogenesis; Motor system disorder; Parkinson disease; Discoveries; Mechanism; Aggregation; Degradation; Degenerative disease; Neurological disorder; Age; Human; Nervous system diseases; Neuroinflammation; Catecholamine; Monogenic; Protein; Cerebral disorder; Anatomic pathology; Dysfunction; Central nervous system disease; Neurotransmitter; Intracellular; Extrapyramidal syndrome

•The molecular pathways involved in Parkinson's disease are extensively described.•The aforementioned pathways are linked to the oxidative chemistry of dopamine.•The reactions of dopamine-derived quinones with cellular targets are emphasized.•Dopamine-derived quinones could contribute to the pr...