Effect of different doses of esketamine on the median effective concentration of propofol for inhibiting body movement during hysteroscopy

• Published in: Scientific reports Vol. 14; no. 1; pp. 25153 - 12
• Main Authors: Wan, Ji-Xiang, Zeng, Si-Si, Wu, Zhi-Qiang, Wang, Yuan, Wang, Na, Wang, Fang-Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.10.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154; 631/154/436; 692/308; 692/308/2779; Adult; Anesthesia; Anesthetics; Anesthetics, Intravenous - administration & dosage; Anxiety; Clinical trials; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; EC50; Esketamine; Female; Hospitals; Humanities and Social Sciences; Humans; Hypertension; Hysteroscopy; Hysteroscopy - methods; Injection; Intravenous administration; Ketamine; Ketamine - administration & dosage; Mental depression; Midazolam; Middle Aged; Movement - drug effects; multidisciplinary; Narcotics; Patients; Pharmacodynamics; Propofol; Propofol - administration & dosage; Prospective Studies; Registration; Science; Science (multidisciplinary); Surgery; Esketamine; Hysteroscopy; Propofol; Anesthetics; EC; EC50
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-75902-3

The objective of this study is to investigate the effects of various doses of esketamine on the median effective concentration (EC 50 ) of propofol required for inhibiting body movement during hysteroscopy. Additionally, this research aims to explore the pharmacodynamic interactions between esketami...