TNFα promotes osteogenic differentiation of human mesenchymal stem cells by triggering the NF-κB signaling pathway

• Published in: Bone (New York, N.Y.) Vol. 45; no. 2; pp. 367 - 376
• Main Authors: Hess, Katrin, Ushmorov, Alexey, Fiedler, Jörg, Brenner, Rolf E., Wirth, Thomas
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.08.2009; Elsevier
• Subjects: Biological and medical sciences; Bone morphogenic protein 2 (BMP-2); Cell physiology; Fundamental and applied biological sciences. Psychology; Matrix mineralization; Mesenchymal stem cells; Mineralization, calcification; Molecular and cellular biology; Nuclear factor kappaB (NF-κB); Orthopedics; Osteogenic differentiation; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Matrix mineralization; Osteogenic differentiation; Nuclear factor kappaB (NF-κB); Bone morphogenic protein 2 (BMP-2); Mesenchymal stem cells; Human; Stem cell; Mesenchymal cell; Bone morphogenetic protein-2; Mineralization; Morphology; Transcription factor NFκB; Bone; Tumor necrosis factor α

Mesenchymal stem cells are multipotent cells able to differentiate into different mesenchymal lineages. Studies in the past had suggested that two of these mesenchymal differentiation directions, the chondrogenic and the myogenic differentiation, are negatively regulated by the transcription factor...