Expression levels and DNA methylation profiles of the growth gene SHOX in cartilage tissues and chondrocytes

• Published in: Scientific reports Vol. 14; no. 1; p. 8069
• Main Authors: Hattori, Atsushi, Seki, Atsuhito, Inaba, Naoto, Nakabayashi, Kazuhiko, Takeda, Kazue, Tatsusmi, Kuniko, Naiki, Yasuhiro, Nakamura, Akie, Ishiwata, Keisuke, Matsumoto, Kenji, Nasu, Michiyo, Okamura, Kohji, Michigami, Toshimi, Katoh-Fukui, Yuko, Umezawa, Akihiro, Ogata, Tsutomu, Kagami, Masayo, Fukami, Maki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.04.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/136/2442; 631/208/176/1988; 631/208/199; 692/308/2056; Adult; Bisulfite; Cartilage; Cartilage - metabolism; Child; Chondrocytes; Chondrocytes - metabolism; CpG islands; Deoxyribonucleic acid; DNA; DNA Methylation; DNA microarrays; Epigenesis, Genetic; Epigenetics; Female; Females; Genes; Homeodomain Proteins - genetics; Humanities and Social Sciences; Humans; Inactivation; Male; multidisciplinary; Science; Science (multidisciplinary); Sex differences; Short Stature Homeobox Protein - genetics; Transcriptomes; X-chromosome inactivation

All attempts to identify male-specific growth genes in humans have failed. This study aimed to clarify why men are taller than women. Microarray-based transcriptome analysis of the cartilage tissues of four adults and chondrocytes of 12 children showed that the median expression levels of SHOX , a g...