Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy

Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to differentiate into multiple cell types. Several studies have shown that exosomes secreted by MSCs (MSCs-Exo) play an important role in tumor growth, angiogenesis, invasion, and drug resistance. However, contradictor...

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Published inCancer letters Vol. 526; pp. 29 - 40
Main Authors Zhang, Fusheng, Guo, Jinshuai, Zhang, Zhenghou, Qian, Yiping, Wang, Guang, Duan, Meiqi, Zhao, Haiying, Yang, Zhi, Jiang, Xiaofeng
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.02.2022
Elsevier Limited
Subjects
Angiogenesis
Body fat
Bone marrow
Cancer therapies
Cell cycle
Cell differentiation
Cell growth
Clinical trials
Cytokines
Drug delivery
Drug resistance
Exosomes
Exosomes - metabolism
Fibroblasts
Gastric cancer
Genotype & phenotype
Humans
Immune response
Immunomodulatory
Immunosuppressive agents
Kinases
Ligands
Medical prognosis
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Metastasis
MicroRNAs
Neoplasms - therapy
Signal transduction
Stem cells
Stromal cells
Targeted tumor therapy
Tumor associated MSCs-derived exosomes
Tumors
Umbilical cord
Drug delivery
Immunomodulatory
Targeted tumor therapy
Tumor associated MSCs-derived exosomes
Mesenchymal stem cells
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Abstract Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to differentiate into multiple cell types. Several studies have shown that exosomes secreted by MSCs (MSCs-Exo) play an important role in tumor growth, angiogenesis, invasion, and drug resistance. However, contradictory results have suggested that MSCs-Exo can also suppress tumors through specific mechanisms, such as regulating immune responses and intercellular signaling. Consequently, the relationship between MSCs-Exo and tumors remains controversial. However, it is undeniable that exosomes, as natural vesicles, can be excellent drug carriers and show promise for application in targeted tumor therapy. Here, we review the current knowledge regarding the involvement of MSCs-Exo in tumor progression and their potential as drug delivery systems in targeted therapy. We argue that MSCs‐Exo can be used as safe carriers of antitumor drugs. •MSCs-Exo can regulate tumor progression through tumor microenvironment remodeling.•MSCs-Exo can be used for targeted tumor therapy by certain means such as engineering and folic acid receptors.•MSCs-Exo is an excellent carrier for chemotherapeutic agents and shows promising applications.
AbstractList Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to differentiate into multiple cell types. Several studies have shown that exosomes secreted by MSCs (MSCs-Exo) play an important role in tumor growth, angiogenesis, invasion, and drug resistance. However, contradictory results have suggested that MSCs-Exo can also suppress tumors through specific mechanisms, such as regulating immune responses and intercellular signaling. Consequently, the relationship between MSCs-Exo and tumors remains controversial. However, it is undeniable that exosomes, as natural vesicles, can be excellent drug carriers and show promise for application in targeted tumor therapy. Here, we review the current knowledge regarding the involvement of MSCs-Exo in tumor progression and their potential as drug delivery systems in targeted therapy. We argue that MSCs-Exo can be used as safe carriers of antitumor drugs.
Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to differentiate into multiple cell types. Several studies have shown that exosomes secreted by MSCs (MSCs-Exo) play an important role in tumor growth, angiogenesis, invasion, and drug resistance. However, contradictory results have suggested that MSCs-Exo can also suppress tumors through specific mechanisms, such as regulating immune responses and intercellular signaling. Consequently, the relationship between MSCs-Exo and tumors remains controversial. However, it is undeniable that exosomes, as natural vesicles, can be excellent drug carriers and show promise for application in targeted tumor therapy. Here, we review the current knowledge regarding the involvement of MSCs-Exo in tumor progression and their potential as drug delivery systems in targeted therapy. We argue that MSCs‐Exo can be used as safe carriers of antitumor drugs. •MSCs-Exo can regulate tumor progression through tumor microenvironment remodeling.•MSCs-Exo can be used for targeted tumor therapy by certain means such as engineering and folic acid receptors.•MSCs-Exo is an excellent carrier for chemotherapeutic agents and shows promising applications.
Author Guo, Jinshuai
Zhao, Haiying
Zhang, Fusheng
Zhang, Zhenghou
Wang, Guang
Duan, Meiqi
Jiang, Xiaofeng
Qian, Yiping
Yang, Zhi
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  givenname: Fusheng
  surname: Zhang
  fullname: Zhang, Fusheng
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  surname: Zhang
  fullname: Zhang, Zhenghou
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  surname: Qian
  fullname: Qian, Yiping
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  givenname: Guang
  surname: Wang
  fullname: Wang, Guang
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  surname: Duan
  fullname: Duan, Meiqi
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
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  givenname: Haiying
  surname: Zhao
  fullname: Zhao, Haiying
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
– sequence: 8
  givenname: Zhi
  surname: Yang
  fullname: Yang, Zhi
  email: yangzhi0910@163.com
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
– sequence: 9
  givenname: Xiaofeng
  orcidid: 0000-0002-5483-8111
  surname: Jiang
  fullname: Jiang, Xiaofeng
  email: 18900912171@163.com
  organization: Department of General Surgery, the Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34800567$$D View this record in MEDLINE/PubMed
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Keywords Drug delivery
Immunomodulatory
Targeted tumor therapy
Tumor associated MSCs-derived exosomes
Mesenchymal stem cells
Language English
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Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.
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Snippet Mesenchymal stem cells (MSCs) are multipotent stromal cells that have the ability to differentiate into multiple cell types. Several studies have shown that...
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SubjectTerms Angiogenesis
Body fat
Bone marrow
Cancer therapies
Cell cycle
Cell differentiation
Cell growth
Clinical trials
Cytokines
Drug delivery
Drug resistance
Exosomes
Exosomes - metabolism
Fibroblasts
Gastric cancer
Genotype & phenotype
Humans
Immune response
Immunomodulatory
Immunosuppressive agents
Kinases
Ligands
Medical prognosis
Mesenchymal stem cells
Mesenchymal Stem Cells - metabolism
Metastasis
MicroRNAs
Neoplasms - therapy
Signal transduction
Stem cells
Stromal cells
Targeted tumor therapy
Tumor associated MSCs-derived exosomes
Tumors
Umbilical cord
Title Mesenchymal stem cell-derived exosome: A tumor regulator and carrier for targeted tumor therapy
URI https://dx.doi.org/10.1016/j.canlet.2021.11.015
https://www.ncbi.nlm.nih.gov/pubmed/34800567
https://www.proquest.com/docview/2611131201
https://search.proquest.com/docview/2600284083
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