Regulation viral RNA transcription and replication by higher-order RNA structures within the nsp1 coding region of MERS coronavirus

• Published in: Scientific reports Vol. 14; no. 1; pp. 19594 - 14
• Main Authors: Terada, Yutaka, Amarbayasgalan, Sodbayasgalan, Matsuura, Yoshiharu, Kamitani, Wataru
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 3' Untranslated regions; 3' Untranslated Regions - genetics; 631/326; 631/326/596; Animals; Artificial chromosomes; Bacterial artificial chromosomes; Coronaviruses; COVID-19; Gene regulation; Genetics; Genomics; Humanities and Social Sciences; Humans; Middle East respiratory syndrome; Middle East Respiratory Syndrome Coronavirus - genetics; multidisciplinary; Nucleic Acid Conformation; Open Reading Frames - genetics; Protein structure; Replication; Respiratory diseases; Ribonucleic acid; RNA; RNA viruses; RNA, Viral - genetics; RNA, Viral - metabolism; Science; Science (multidisciplinary); Secondary structure; Transcription, Genetic; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Virus Replication - genetics

Coronavirus (CoV) possesses numerous functional cis-acting elements in its positive-strand genomic RNA. Although most of these RNA structures participate in viral replication, the functions of RNA structures in the genomic RNA of CoV in viral replication remain unclear. In this study, we investigate...