A durable protective immune response to wild-type measles virus infection of macaques is due to viral replication and spread in lymphoid tissues

• Published in: Science translational medicine Vol. 12; no. 537
• Main Authors: Lin, Wen-Hsuan W, Moran, Eileen, Adams, Robert J, Sievers, Robert E, Hauer, Debra, Godin, Steven, Griffin, Diane E
• Format: Journal Article
• Language: English
• Published: United States 01.04.2020
• Subjects: Animals; Antibodies, Viral; Female; Leukocytes, Mononuclear; Lymphoid Tissue; Macaca mulatta; Male; Measles; Measles virus - immunology; Virus Replication

Infection with wild-type (WT) measles virus (MeV) is an important cause of childhood mortality that leads to lifelong protective immunity in survivors. WT MeV and the live-attenuated MeV used in the measles vaccine (LAMV) are antigenically similar, but the determinants of attenuation are unknown, an...