Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis

• Published in: Frontiers in pharmacology Vol. 14; p. 1132367
• Main Authors: Chen, Chao-Yang, Xie, Min, Gong, Jun, Yu, Ning, Wei, Ran, Lei, Li-Li, Zhao, Si-Miao, Li, Ruo-Ming, Dong, Xiu, Zhang, Xiang-Lin, Zhou, Ying, Li, Shuang-Ling, Cui, Yi-Min
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 28.04.2023
• Subjects: dosing optimization; Monte Carlo simulation; Pharmacology; population pharmacokinetics; sepsis; teicoplanin; teicoplanin; dosing optimization; Monte Carlo simulation; sepsis; population pharmacokinetics

Teicoplanin has been extensively used in the treatment for infections caused by gram-positive bacteria including methicillin-resistant (MRSA). However, current teicoplanin treatment is challenging due to relatively low and variable concentrations under standard dosage regimens. This study aimed to i...