Organoid Technology and Clinical Applications in Digestive System Cancer

• Published in: Engineering (Beijing, China) Vol. 9; no. 2; pp. 123 - 130
• Main Authors: Zhao, Xiaofang, Jiang, Youhai, Liu, Chunliang, Hou, Minghui, Wang, Hongyang, Fu, Jing
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.02.2022; International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Cancer Research Center,The First Affiliated Hospital ofUSTC,Department of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China; Fudan University Shanghai Cancer Center,Shanghai 200032,China; Elsevier
• Subjects: Digestive system cancer; Organoid; Precision medicine; Precision medicine; Digestive system cancer; Organoid

Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide. Current cancer models cannot faithfully recapitulate the critical features of the original tumor, resulting in the failure of translation fro...