Organoid Technology and Clinical Applications in Digestive System Cancer

Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide. Current cancer models cannot faithfully recapitulate the critical features of the original tumor, resulting in the failure of translation fro...

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Published inEngineering (Beijing, China) Vol. 9; no. 2; pp. 123 - 130
Main Authors Zhao, Xiaofang, Jiang, Youhai, Liu, Chunliang, Hou, Minghui, Wang, Hongyang, Fu, Jing
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.02.2022
International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Cancer Research Center,The First Affiliated Hospital ofUSTC,Department of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
Fudan University Shanghai Cancer Center,Shanghai 200032,China
Elsevier
Subjects
Digestive system cancer
Organoid
Precision medicine
Precision medicine
Digestive system cancer
Organoid
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Abstract Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide. Current cancer models cannot faithfully recapitulate the critical features of the original tumor, resulting in the failure of translation from basic research into clinical practice. More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development. Organoids are in vitro cultured three dimensional (3D) self-organizing organotypic structures derived from tissues and pluripotent stem cells, which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues. Both normal and malignant organoids can now be efficiently established from the DS tissues of patients. In this review, we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research, preclinical medical practice, and precision medicine.
AbstractList Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality worldwide.Current cancer models cannot faithfully recapitu-late the critical features of the original tumor,resulting in the failure of translation from basic research into clinical practice.More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development.Organoids are in vitro cultured three dimensional(3D)self-organizing organotypic structures derived from tissues and pluripotent stem cells,which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues.Both normal and malignant organoids can now be efficiently established from the DS tissues of patients.In this review,we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research,preclinical medical practice,and precision medicine.
Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide. Current cancer models cannot faithfully recapitulate the critical features of the original tumor, resulting in the failure of translation from basic research into clinical practice. More advanced cancer models are in urgent need of pathogenesis exploration and anticancer medicine development. Organoids are in vitro cultured three dimensional (3D) self-organizing organotypic structures derived from tissues and pluripotent stem cells, which faithfully mimic the histological features and preserve the genetic heterogeneity of the original tissues. Both normal and malignant organoids can now be efficiently established from the DS tissues of patients. In this review, we summarize the general methods to generate human DS organoids and their applications as a novel model in basic cancer research, preclinical medical practice, and precision medicine.
Author Hou, Minghui
Jiang, Youhai
Zhao, Xiaofang
Liu, Chunliang
Wang, Hongyang
Fu, Jing
AuthorAffiliation Fudan University Shanghai Cancer Center,Shanghai 200032,China;International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Cancer Research Center,The First Affiliated Hospital ofUSTC,Department of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
AuthorAffiliation_xml – name: Fudan University Shanghai Cancer Center,Shanghai 200032,China;International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Cancer Research Center,The First Affiliated Hospital ofUSTC,Department of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
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CitedBy_id crossref_primary_10_1016_j_xinn_2024_100620
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Digestive system cancer
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International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Cancer Research Center,The First Affiliated Hospital ofUSTC,Department of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230031,China%International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer,Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor Biology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China%Department of Oncology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China
Fudan University Shanghai Cancer Center,Shanghai 200032,China
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Snippet Cancers of the digestive system (DS), including esophageal, gastric, colorectal, liver, and pancreatic cancers, have a high incidence and mortality worldwide....
Cancers of the digestive system(DS),including esophageal,gastric,colorectal,liver,and pancreatic can-cers,have a high incidence and mortality worldwide.Current...
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SubjectTerms Digestive system cancer
Organoid
Precision medicine
Title Organoid Technology and Clinical Applications in Digestive System Cancer
URI https://dx.doi.org/10.1016/j.eng.2021.04.017
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