Colloidal hydrogels made of gelatin nanoparticles exhibit fast stress relaxation at strains relevant for cell activity

• Published in: Acta biomaterialia Vol. 138; pp. 124 - 132
• Main Authors: Bertsch, Pascal, Andrée, Lea, Besheli, Negar Hassani, Leeuwenburgh, Sander C.G.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.01.2022; Elsevier BV
• Subjects: Biocompatible Materials; Biomaterial design; Biomaterials; Biomedical materials; Cell culture; Cell differentiation; Cell fate; Cell mobility; Cell proliferation; Cellular communication; Colloiding; Elasticity; Fluidization; Fluidizing; Gelatin; Gels; Hydrogel; Hydrogels; Hydrogels - pharmacology; Mechanical properties; Nanoparticles; Particle interactions; Regenerative medicine; Rheological properties; Rheology; Strain; Stress; Stress relaxation; Tissue Engineering; Viscoelasticity; Viscoelasticity; Cell culture; Tissue engineering; Rheology; Cell mobility; Biomaterial design; Hydrogel

Viscoelastic properties of hydrogels such as stress relaxation or plasticity have been recognized as important mechanical cues that dictate the migration, proliferation, and differentiation of embedded cells. Stress relaxation rates in conventional hydrogels are usually much slower than cellular pro...