A substantia innominata-midbrain circuit controls a general aggressive response

• Published in: Neuron (Cambridge, Mass.) Vol. 109; no. 9; pp. 1540 - 1553.e9
• Main Authors: Zhu, Zhenggang, Ma, Qingqing, Miao, Lu, Yang, Hongbin, Pan, Lina, Li, Kaiyuan, Zeng, Ling-Hui, Zhang, Xiaoxing, Wu, Jintao, Hao, Sijia, Lin, Shen, Ma, Xiulin, Mai, Weihao, Feng, Xiang, Hao, Yizhe, Sun, Li, Duan, Shumin, Yu, Yan-qin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.05.2021; Elsevier Limited
• Subjects: Aggression; Aggressive behavior; aggressive state; Aggressiveness; Arousal; Behavior; Brain; defensive behavior; female; Females; Kinases; Mating behavior; Mesencephalon; Neural networks; periaqueductal gray; Periaqueductal gray area; posterior substantia innominata; Substantia innominata; Threats; defensive behavior; aggression; aggressive state; female; periaqueductal gray; posterior substantia innominata; arousal

Although aggressive behaviors are universal and essential for survival, “uncontrollable” and abnormal aggressive behaviors in animals or humans may have severe adverse consequences or social costs. Neural circuits regulating specific forms of aggression under defined conditions have been described,...