Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish ( Danio rerio ) Model

The Ayurvedic medical system uses fruits of the plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of fruit's ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which incl...

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Published inLife (Basel, Switzerland) Vol. 14; no. 3; p. 379
Main Authors Lakshmanagowda, Nityashree Kyathegowdanadoddi, Sagar, Niju, Puttasiddaiah, Rachitha, Sridhar, Kandi, Raghavendra, Vinay Basavegowda, Bhaswant, Maharshi
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.03.2024
MDPI
Subjects
Acetylcholinesterase
antianxiety
antistress
Anxiety
behavioral parameters
Benincasa hispida
Carbohydrates
Chloride
Danio rerio
Drinking water
Evaluation
Flavonoids
Fruits
Herbal medicine
Hydrogen peroxide
Mental disorders
Nitric oxide
Oils & fats
Oxidative stress
Physiology
Reagents
Schizophrenia
Steroids
Survival
therapeutic molecule
Toxicity
Zebrafish
India
antistress
Benincasa hispida
antianxiety
therapeutic molecule
behavioral parameters
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Abstract The Ayurvedic medical system uses fruits of the plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of fruit's ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light-dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC was found to be 5 µg. AChE (acetylcholinesterase) inhibitory activity and the status of antioxidant enzymes (SOD, CAT, and LDH) were also used to evaluate the toxicity. Furthermore, the administration of the aqueous extract of fruit increased the frequency of entry and duration of time spent in the bright section, suggesting a noteworthy reduction in levels of stress and anxiety. Additionally, the antistress and antianxiety activity was confirmed by the docking studies' mechanism of action, which involves the AChE receptor binding stability of the homogalactaconan molecule found in the aqueous extract of fruit. Overall, the findings of this study demonstrated that the aqueous extract of fruit is a viable therapeutic molecule for the creation of novel drugs and the treatment of stress since it has the therapeutic advantage of reversing the negative effects of stress and anxiety.
AbstractList The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of B. hispida fruit’s ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light–dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC50 was found to be 5 µg. AChE (acetylcholinesterase) inhibitory activity and the status of antioxidant enzymes (SOD, CAT, and LDH) were also used to evaluate the toxicity. Furthermore, the administration of the aqueous extract of B. hispida fruit increased the frequency of entry and duration of time spent in the bright section, suggesting a noteworthy reduction in levels of stress and anxiety. Additionally, the antistress and antianxiety activity was confirmed by the docking studies’ mechanism of action, which involves the AChE receptor binding stability of the homogalactaconan molecule found in the aqueous extract of B. hispida fruit. Overall, the findings of this study demonstrated that the aqueous extract of B. hispida fruit is a viable therapeutic molecule for the creation of novel drugs and the treatment of stress since it has the therapeutic advantage of reversing the negative effects of stress and anxiety.
The Ayurvedic medical system uses fruits of the plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of fruit's ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light-dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC was found to be 5 µg. AChE (acetylcholinesterase) inhibitory activity and the status of antioxidant enzymes (SOD, CAT, and LDH) were also used to evaluate the toxicity. Furthermore, the administration of the aqueous extract of fruit increased the frequency of entry and duration of time spent in the bright section, suggesting a noteworthy reduction in levels of stress and anxiety. Additionally, the antistress and antianxiety activity was confirmed by the docking studies' mechanism of action, which involves the AChE receptor binding stability of the homogalactaconan molecule found in the aqueous extract of fruit. Overall, the findings of this study demonstrated that the aqueous extract of fruit is a viable therapeutic molecule for the creation of novel drugs and the treatment of stress since it has the therapeutic advantage of reversing the negative effects of stress and anxiety.
The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the aqueous extract of B. hispida fruit’s ability to relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters in tests such as the T-maze, open tank test (OTT), and light–dark preference test (LDPT). After measuring the zebrafish survival rate for 96 h, the LC 50 was found to be 5 µg. AChE (acetylcholinesterase) inhibitory activity and the status of antioxidant enzymes (SOD, CAT, and LDH) were also used to evaluate the toxicity. Furthermore, the administration of the aqueous extract of B. hispida fruit increased the frequency of entry and duration of time spent in the bright section, suggesting a noteworthy reduction in levels of stress and anxiety. Additionally, the antistress and antianxiety activity was confirmed by the docking studies’ mechanism of action, which involves the AChE receptor binding stability of the homogalactaconan molecule found in the aqueous extract of B. hispida fruit. Overall, the findings of this study demonstrated that the aqueous extract of B. hispida fruit is a viable therapeutic molecule for the creation of novel drugs and the treatment of stress since it has the therapeutic advantage of reversing the negative effects of stress and anxiety.
Author Raghavendra, Vinay Basavegowda
Lakshmanagowda, Nityashree Kyathegowdanadoddi
Bhaswant, Maharshi
Sridhar, Kandi
Sagar, Niju
Puttasiddaiah, Rachitha
AuthorAffiliation 5 Center for Molecular and Nanomedical Sciences, Sathyabama Institute of Science and Technology, Chennai 600119, India
3 Department of Food Technology, Karpagam Academy of Higher Education (Deemed to be University), Coimbatore 641021, India; sridhar4647@gmail.com
1 Department of Clinical Psychology, JSS Medical College and Hospital, Mysuru 570015, India; nityashree.30@gmail.com
4 New Industry Creation Hatchery Center, Tohoku University, Sendai 9808579, Japan
2 Teresian College Research Center, Teresian College, Mysore 570011, India; nijusagar2204@gmail.com (N.S.); biotechrachitha@gmail.com (R.P.)
AuthorAffiliation_xml – name: 2 Teresian College Research Center, Teresian College, Mysore 570011, India; nijusagar2204@gmail.com (N.S.); biotechrachitha@gmail.com (R.P.)
– name: 4 New Industry Creation Hatchery Center, Tohoku University, Sendai 9808579, Japan
– name: 3 Department of Food Technology, Karpagam Academy of Higher Education (Deemed to be University), Coimbatore 641021, India; sridhar4647@gmail.com
– name: 1 Department of Clinical Psychology, JSS Medical College and Hospital, Mysuru 570015, India; nityashree.30@gmail.com
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Issue 3
Keywords antistress
Benincasa hispida
antianxiety
therapeutic molecule
behavioral parameters
Language English
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Snippet The Ayurvedic medical system uses fruits of the plant to treat mental diseases, including schizophrenia. The goal of the current study was to assess the...
The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. The goal of the current study was to...
The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. The goal of the current study was to...
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SubjectTerms Acetylcholinesterase
antianxiety
antistress
Anxiety
behavioral parameters
Benincasa hispida
Carbohydrates
Chloride
Danio rerio
Drinking water
Evaluation
Flavonoids
Fruits
Herbal medicine
Hydrogen peroxide
Mental disorders
Nitric oxide
Oils & fats
Oxidative stress
Physiology
Reagents
Schizophrenia
Steroids
Survival
therapeutic molecule
Toxicity
Zebrafish
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Title Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish ( Danio rerio ) Model
URI https://www.ncbi.nlm.nih.gov/pubmed/38541704
https://www.proquest.com/docview/3003314391/abstract/
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https://doaj.org/article/ba5d1979db104fa398ef71e7ac911aa6
Volume 14
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