Deep learning for drug response prediction in cancer

• Published in: Briefings in bioinformatics Vol. 22; no. 1; pp. 360 - 379
• Main Authors: Baptista, Delora, Ferreira, Pedro G, Rocha, Miguel
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.01.2021; Oxford Publishing Limited (England)
• Subjects: Algorithms; Biotechnology; Cancer; Deep learning; Drug screening; High-throughput screening; Learning algorithms; Machine learning; Precision medicine; Prediction models; Predictions; Tumor cell lines; Tumors; drug synergy; deep learning; precision medicine; drug sensitivity; cancer

Abstract Predicting the sensitivity of tumors to specific anti-cancer treatments is a challenge of paramount importance for precision medicine. Machine learning(ML) algorithms can be trained on high-throughput screening data to develop models that are able to predict the response of cancer cell line...