C-C and C-X coupling reactions of unactivated alkyl electrophiles using copper catalysis

• Published in: Chemical Society reviews Vol. 49; no. 22; pp. 836 - 864
• Main Authors: Cheng, Li-Jie, Mankad, Neal P
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 21.11.2020
• Subjects: Aromatic compounds; Carbenes; Carbon; catalytic activity; Chemical reactions; Copper; Cross coupling; cross-coupling reactions; Grignard reagents; heterocyclic nitrogen compounds; Lewis acids; ligands; Phosphines; Reagents; society; Transition metals

Transition metal-catalysed cross-coupling reactions are widely used for construction of carbon-carbon and carbon-heteroatom bonds. However, compared to aryl or alkenyl electrophiles, the cross-coupling of unactivated alkyl electrophiles containing β hydrogens remains a challenge. Over the past few y...