An omics perspective on drug target discovery platforms

• Published in: Briefings in bioinformatics Vol. 21; no. 6; pp. 1937 - 1953
• Main Authors: Paananen, Jussi, Fortino, Vittorio
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2020; Oxford Publishing Limited (England)
• Subjects: Biomedical data; Computer applications; Data sources; Deoxyribonucleic acid; DNA; Evaluation; Graphical user interface; Interfaces; Knowledge bases (artificial intelligence); Metabolites; Platforms; Review; Ribonucleic acid; RNA; Side effects; Target recognition; Therapeutic targets; drug target discovery; drug efficacy and safety evaluations; omics-informed drug discovery

Abstract The drug discovery process starts with identification of a disease-modifying target. This critical step traditionally begins with manual investigation of scientific literature and biomedical databases to gather evidence linking molecular target to disease, and to evaluate the efficacy, safe...