The effects of deformation, ischemia, and reperfusion on the development of muscle damage during prolonged loading

• Published in: Journal of applied physiology (1985) Vol. 111; no. 4; pp. 1168 - 1177
• Main Authors: Loerakker, S., Manders, E., Strijkers, G. J., Nicolay, K., Baaijens, F. P. T., Bader, D. L., Oomens, C. W. J.
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Physiological Society 01.10.2011
• Subjects: Animals; Biological and medical sciences; Deformation; Female; Fundamental and applied biological sciences. Psychology; Ischemia; Ischemia - pathology; Magnetic Resonance Imaging - methods; Muscle, Skeletal - blood supply; Muscle, Skeletal - pathology; Muscular Diseases - pathology; Muscular system; NMR; Nuclear magnetic resonance; Rats; Reperfusion - methods; Reperfusion Injury - pathology; Stress, Mechanical; Tissues; Skin disease; magnetic resonance imaging; Deformation; Ischemia reperfusion; finite element modeling; Pressure sore; Striated muscle; Nuclear magnetic resonance imaging; Modeling; Vertebrata; Mammalia; Development; pressure ulcers; skeletal muscle; Prolonged

Deep tissue injury (DTI) is a severe form of pressure ulcer where tissue damage starts in deep tissues underneath intact skin. In the present study, the contributions of deformation, ischemia, and reperfusion to skeletal muscle damage development were examined in a rat model during a 6-h period. Mag...