Regulation of the endogenous NO pathway by prolonged inhaled NO in rats

• Published in: Journal of applied physiology (1985) Vol. 85; no. 3; pp. 1070 - 1078
• Main Authors: Frank, Deborah U, Horstman, Damian J, Morris, Geoffrey N, Johns, Roger A, Rich, George F
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.09.1998; American Physiological Society
• Subjects: Administration, Inhalation; Anatomy & physiology; Animals; Biological and medical sciences; Blotting, Western; Chromatography, Gas; Cyclic GMP - physiology; Endothelium, Vascular - physiology; Gases; Guanylate Cyclase - antagonists & inhibitors; Guanylate Cyclase - metabolism; Hypertension; Hypoxia - physiopathology; In Vitro Techniques; Male; Medical sciences; Nitric Oxide - administration & dosage; Nitric Oxide - pharmacology; Nitric Oxide - physiology; Nitric Oxide Synthase - biosynthesis; Nitric Oxide Synthase - genetics; Nitric Oxide Synthase Type III; Pneumology; Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases; Rats; Rats, Sprague-Dawley; Respiratory system; Rodents; Signal Transduction - drug effects; Signal Transduction - physiology; Vasodilation - drug effects; Vasodilation - physiology; Animal model; Oxygen; Rat; Respiratory disease; Enzyme; Rodentia; Cardiovascular disease; Environmental factor; 3',5'-GMP; Metabolic pathway; Pulmonary hypertension; Nitric-oxide synthase; Vertebrata; Chronic; Regulation(control); Mammalia; Animal; Nitric oxide; Hypoxia; Oxidoreductases

Departments of 1  Biomedical Engineering and 2  Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22906-0010 Nitric oxide (NO) modulates the endogenous NO-cGMP pathway. We determined whether prolonged inhaled NO downregulates the NO-cGMP pathway, which may explain clini...