Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1/HO-1 axis in inflammatory bowel diseases

• Published in: Free radical biology & medicine Vol. 163; pp. 1 - 9
• Main Authors: Dun Su, Wang, Xingwen, Ma, Yan, Hao, Jinghua, Jinshen Wang, Yongqu Lu, Yulin Liu, Xingfang Wang, Zhang, Li
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2021
• Subjects: Bach1; HO-1; IBD; miR-23a-27a-24-2 cluster; Nrf2; TNFα; ORF; miRNAs; IHC; CTLs; HO-1; IBD; WB; UC; CHIP; Nrf2; RT-PCR; MAREs; IC; β-gal; AGE; CD; Bach1; DSS; 3′UTR; qRT-PCR; CT; ARE; miR-23a-27a-24-2 cluster; NK; HE

IBD is an idiopathic, chronic autoimmune disease associated with intense oxidative stress. As a master modulator of oxidative stress, Nrf2 has an important anti-inflammatory role in colitis by activating HO-1 transcription. Meanwhile, HO-1 expression is transcriptionally suppressed by Bach1. The Nrf...