Modeling critical dosing strategies for stromal-induced resistance to cancer therapy

• Published in: NPJ systems biology and applications Vol. 11; no. 1; pp. 16 - 17
• Main Authors: Kraut, Anna K., Garvey, Colleen M., Strelez, Carly, Mumenthaler, Shannon M., Foo, Jasmine
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/67; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Bioinformatics; Biology; Biomedical and Life Sciences; Cancer; Cancer therapies; Cell Line, Tumor; Cetuximab - administration & dosage; Cetuximab - pharmacology; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - pathology; Combination therapy; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug resistance; Drug Resistance, Neoplasm - drug effects; Environmental factors; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - metabolism; Fibroblasts; Humans; Life Sciences; Lung cancer; Mathematical models; Melanoma; Models, Biological; Monoclonal antibodies; Neoplasms - drug therapy; Neoplasms - pathology; Optimization; Ordinary differential equations; Secretome; Stromal cells; Stromal Cells - drug effects; Stromal Cells - metabolism; Stromal Cells - pathology; Systems Biology; Tumor cells; Tumor Microenvironment - drug effects; Tumors

Complex interactions between stromal cells, tumor cells and therapies can influence environmental factors that in turn impact anticancer treatment efficacy. Disentangling these phenomena is critical for understanding treatment response and designing effective dosing strategies. We propose a mathemat...