Modeling critical dosing strategies for stromal-induced resistance to cancer therapy - Kraut, Anna K.; Garvey, Colleen M.; Strelez, Carly; Mumenthaler, Shannon M.; Foo, Jasmine (NPJ systems biology and applications, 2025)
Keywords: 631/114; 631/67; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Bioinformatics; Biology; Biomedical and Life Sciences; Cancer; Cancer therapies; Cell Line, Tumor; Cetuximab - administration & dosage; Cetuximab - pharmacology; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - pathology; Combination therapy; Computational Biology/Bioinformatics; Computer Appl. in Life Sciences; Dosage; Dose-Response Relationship, Drug; Drug dosages; Drug resistance; Drug Resistance, Neoplasm - drug effects; Environmental factors; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - antagonists & inhibitors; ErbB Receptors - metabolism; Fibroblasts; Humans; Life Sciences; Lung cancer; Mathematical models; Melanoma; Models, Biological; Monoclonal antibodies; Neoplasms - drug therapy; Neoplasms - pathology; Optimization; Ordinary differential equations; Secretome; Stromal cells; Stromal Cells - drug effects; Stromal Cells - metabolism; Stromal Cells - pathology; Systems Biology; Tumor cells; Tumor Microenvironment - drug effects; Tumors