CMTM7 shapes the chronic inflammatory and immunosuppressive tumor microenvironment in hepatocellular carcinoma as an M2 macrophage biomarker

• Published in: Scientific reports Vol. 14; no. 1; pp. 29659 - 16
• Main Authors: Zhu, Zhipeng, Liu, Hanzhi, Fu, Huafeng, Luo, Yu, Chen, Baisheng, Wu, Xiaofang, Sun, Anran, Zhang, Fuxing, Wang, Tao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/580; 631/67/1059; 631/67/1857; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer immunotherapy; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - immunology; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Chemokines; Chronic inflammation; Female; Gene Expression Regulation, Neoplastic; Hepatocellular carcinoma; Humanities and Social Sciences; Humans; Immune checkpoint; Immune Tolerance; Immunosuppression; Immunotherapy; Infiltration; Inflammation; Inflammation - metabolism; Inflammation - pathology; Liver cancer; Liver Neoplasms - genetics; Liver Neoplasms - immunology; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Lymphocytes T; Macrophage; Macrophages; Macrophages - immunology; Macrophages - metabolism; Male; MARVEL Domain-Containing Proteins - genetics; MARVEL Domain-Containing Proteins - metabolism; Metastases; multidisciplinary; Myelin Proteins - genetics; Myelin Proteins - metabolism; Prognosis; Science; Science (multidisciplinary); Sequence analysis; Transmembrane domain containing 7; Transmembrane domains; Tumor cells; Tumor microenvironment; Tumor Microenvironment - immunology; Tumors; Hepatocellular carcinoma; Immunosuppression; Tumor microenvironment; Transmembrane domain containing 7; Chronic inflammation; Macrophage

Transmembrane domain-containing 7 (CMTM7) is a protein located at the plasma membrane. It plays a role in regulating the development and immune microenvironment of tumor cells. However, the impact of CMTM7 on hepatocellular carcinoma (HCC) is not well understood. To better understand the role of CMT...