Reactivity of ynamides in catalytic intermolecular annulations

• Published in: Chemical Society reviews Vol. 5; no. 4; pp. 2582 - 2625
• Main Authors: Hu, Yan-Cheng, Zhao, Yingying, Wan, Boshun, Chen, Qing-An
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.03.2021
• Subjects: Alkynes; Carbon; Catalysis; catalytic activity; Electrons; Ethers; Lewis acids; Lewis bases; nitrogen; Reactivity; regioselectivity; Transition metals

Ynamides are unique alkynes with a carbon-carbon triple bond directly attached to the nitrogen atom bearing an electron-withdrawing group. The alkyne is strongly polarized by the electron-donating nitrogen atom, but its high reactivity can be finely tempered by the electron-withdrawing group. Accord...