In vivo activity of perifosine against Leishmania amazonensis
Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against Leishmania showing an in vitro antiparasitic activity. Perifosine in vitro activity has been previously demonstra...
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Published in | Acta tropica Vol. 108; no. 1; pp. 20 - 25 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.10.2008
Elsevier |
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Abstract | Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against
Leishmania showing an
in vitro antiparasitic activity. Perifosine
in vitro activity has been previously demonstrated against different
Leishmania species including
Leishmania amazonensis. In this study edelfosine and perifosine were orally administered to
BALB/
c mice at doses of 1 and 2.5
mg/kg/day during 28 days and 5
mg/kg/day during 14 days, starting the treatment 2 weeks after the first treatment scheme. Lesion sizes and parasitic burden as well as viability were determined in order to establish the treatment effectiveness. An assay to compare miltefosine at standard dose of 2.5
mg/kg/day during 28 days to an
in vivo treatment with perifosine at the most effective treatment scheme observed in this study 5
mg/kg/day during 14 days, was also developed. Perifosine showed the higher activity in the
in vivo assay and is showing as a new possibility within the alkyl-phospholipids group for the treatment against cutaneous leishmaniasis caused by
L. amazonensis. |
---|---|
AbstractList | Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against
Leishmania showing an
in vitro antiparasitic activity. Perifosine
in vitro activity has been previously demonstrated against different
Leishmania species including
Leishmania amazonensis. In this study edelfosine and perifosine were orally administered to
BALB/
c mice at doses of 1 and 2.5
mg/kg/day during 28 days and 5
mg/kg/day during 14 days, starting the treatment 2 weeks after the first treatment scheme. Lesion sizes and parasitic burden as well as viability were determined in order to establish the treatment effectiveness. An assay to compare miltefosine at standard dose of 2.5
mg/kg/day during 28 days to an
in vivo treatment with perifosine at the most effective treatment scheme observed in this study 5
mg/kg/day during 14 days, was also developed. Perifosine showed the higher activity in the
in vivo assay and is showing as a new possibility within the alkyl-phospholipids group for the treatment against cutaneous leishmaniasis caused by
L. amazonensis. Miltefosine has been established as the first oral administration drug against cutaneous and visceral leishmaniasis. Other alkyl-phospholipids such as edelfosine have been tested against Leishmania showing an in vitro antiparasitic activity. Perifosine in vitro activity has been previously demonstrated against different Leishmania species including Leishmania amazonensis. In this study edelfosine and perifosine were orally administered to BALB/c mice at doses of 1 and 2.5 mg/kg/day during 28 days and 5 mg/kg/day during 14 days, starting the treatment 2 weeks after the first treatment scheme. Lesion sizes and parasitic burden as well as viability were determined in order to establish the treatment effectiveness. An assay to compare miltefosine at standard dose of 2.5 mg/kg/day during 28 days to an in vivo treatment with perifosine at the most effective treatment scheme observed in this study 5 mg/kg/day during 14 days, was also developed. Perifosine showed the higher activity in the in vivo assay and is showing as a new possibility within the alkyl-phospholipids group for the treatment against cutaneous leishmaniasis caused by L. amazonensis. |
Author | Cabrera-Serra, M. Gabriela Valladares, Basilio Piñero, Jose E. |
Author_xml | – sequence: 1 givenname: M. Gabriela surname: Cabrera-Serra fullname: Cabrera-Serra, M. Gabriela – sequence: 2 givenname: Basilio surname: Valladares fullname: Valladares, Basilio – sequence: 3 givenname: Jose E. surname: Piñero fullname: Piñero, Jose E. email: jpinero@ull.es, mgcabre@ull.es |
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Cites_doi | 10.1016/S1473-3099(05)70296-6 10.1046/j.1365-3156.2001.00795.x 10.4161/cbt.4.10.2064 10.1007/s00436-002-0695-3 10.1128/AAC.49.12.4950-4956.2005 10.1016/j.drup.2004.07.002 10.1016/j.pt.2005.08.026 10.1016/j.trstmh.2006.02.022 10.1128/AAC.45.6.1872-1875.2001 10.1016/j.trstmh.2006.02.009 10.1128/AAC.36.8.1630 10.1111/j.1365-3024.1985.tb00098.x 10.1111/j.1742-7843.2005.pto960109.x 10.1016/S0169-4758(96)40010-2 10.1016/j.actatropica.2006.02.001 10.1093/jac/dkh380 10.1590/S0074-02762000000400006 10.2174/1381612023396258 10.1016/j.cimid.2004.03.004 10.4269/ajtmh.2001.64.187 10.1517/13543776.14.8.1113 10.1007/s00436-006-0408-4 10.1016/S1383-5769(99)00020-3 10.1111/j.1600-065X.2006.00432.x 10.1016/S0001-706X(01)00197-8 10.1086/383321 10.1007/s10637-006-6406-7 10.1128/AAC.39.9.2167 10.1016/S0140-6736(05)67629-5 |
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Keywords | Miltefosine Edelfosine Leishmanicidal activity Perifosine Leishmania amazonensis Parasitic burden Kinetoplastida Antineoplastic agent Protozoa In vivo Tropical medicine |
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SubjectTerms | Administration, Oral Animals Antiprotozoal Agents - administration & dosage Antiprotozoal Agents - therapeutic use Biological and medical sciences Edelfosine Female General aspects Leishmania amazonensis Leishmania mexicana - drug effects Leishmania mexicana - isolation & purification Leishmaniasis, Cutaneous - drug therapy Leishmaniasis, Cutaneous - parasitology Leishmaniasis, Cutaneous - pathology Leishmanicidal activity Medical sciences Mice Mice, Inbred BALB C Miltefosine Parasitic burden Perifosine Phospholipid Ethers - administration & dosage Phospholipid Ethers - therapeutic use Phosphorylcholine - administration & dosage Phosphorylcholine - analogs & derivatives Phosphorylcholine - therapeutic use Survival Analysis |
Title | In vivo activity of perifosine against Leishmania amazonensis |
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