Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb

• Published in: Journal of applied physiology (1985) Vol. 85; no. 3; pp. 1079 - 1085
• Main Authors: Ibe, Basil O, Hibler, Sue, Raj, J. Usha
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.09.1998; American Physiological Society
• Subjects: Air breathing; Anatomy & physiology; Angiotensin II - pharmacology; Animals; Animals, Newborn - physiology; Azepines - pharmacology; Biological and medical sciences; Blood Pressure - drug effects; Blood Pressure - physiology; Female; Fundamental and applied biological sciences. Psychology; Lungs; Muscle Tonus - drug effects; Muscle, Smooth, Vascular - drug effects; Platelet Activating Factor - pharmacology; Platelet Aggregation Inhibitors - pharmacology; Platelet Membrane Glycoproteins - antagonists & inhibitors; Pregnancy; Pulmonary Circulation - drug effects; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics; Sheep; Triazoles - pharmacology; Vascular Resistance - drug effects; Vasoconstrictor Agents - pharmacology; Vertebrates: respiratory system; Smooth muscle; Respiratory system; Platelet activating factor; Resistance; Vertebrata; Mammalia; Postnatal; Pulmonary vessel; Newborn animal; Sheep; Pulmonary circulation; Circulatory system; Artiodactyla; Ungulata; Muscular tonus

Department of Pediatrics, University of California, Los Angeles, School of Medicine, Harbor-UCLA Medical Center, Torrance, California 90502 Eight near-term fetal lambs were studied acutely in utero to determine role of platelet-activating factor (PAF) in the regulation of vasomotor tone in systemic...