Hypogammaglobulinemia and Infection Events in Patients with Autoimmune Diseases Treated with Rituximab: 10 Years Real-Life Experience

• Published in: Journal of clinical immunology Vol. 44; no. 8; p. 179
• Main Authors: Nie, Yuxue, Zhang, Nianyi, Li, Jingna, Wu, Di, Yang, Yunjiao, Zhang, Li, Bai, Wei, Jiang, Nan, Qiao, Lin, Huang, Can, Zhou, Shuang, Tian, Xinping, Li, Mengtao, Zeng, Xiaofeng, Peng, Linyi, Zhang, Wen
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2024; Springer Nature B.V
• Subjects: Adult; Agammaglobulinemia - epidemiology; Aged; Antineutrophil cytoplasmic antibodies; Autoimmune diseases; Autoimmune Diseases - complications; Autoimmune Diseases - drug therapy; Biomedical and Life Sciences; Biomedicine; China; China - epidemiology; Connective tissue diseases; Disease; Female; glucocorticoids; Glucocorticoids - therapeutic use; Humans; Hypogammaglobulinemia; Immunoglobulin G; Immunoglobulin G - blood; Immunoglobulin M; Immunology; Immunotherapy; Infections - epidemiology; Infections - etiology; Infectious Diseases; Internal Medicine; Lung diseases; Male; medical facilities; Medical Microbiology; Middle Aged; Monoclonal antibodies; Patients; Population studies; Prednisone; respiratory tract diseases; Retrospective Studies; Risk Factors; Rituximab; Rituximab - adverse effects; Rituximab - therapeutic use; therapeutics; Vasculitis; China; Rituximab; Autoimmune disease; Immunoglobulins; Hypogammaglobulinemia; Severe infection event

Objectives To investigate predictors of hypogammaglobulinemia (HGG) and severe infection event (SIE) in patients with autoimmune disease (AID) receiving rituximab (RTX) therapy. Methods This was a retrospective study conducted in a tertiary medical center in China. Predictors of HGG or SIE were asse...