Challenges and potential for improving the druggability of podophyllotoxin-derived drugs in cancer chemotherapy - Zhao, Wei; Cong, Ying; Li, Hong-Mei; Li, Shengying; Shen, Yuemao; Qi, Qingsheng; Zhang, Youming; Li, Yue-Zhong; Tang, Ya-Jie (Natural product reports, 2021)
Keywords: Anticancer properties; antineoplastic activity; Antineoplastic Agents - therapeutic use; Antitumor activity; bioactive compounds; Bioavailability; Biocompatibility; Cancer therapies; cancer therapy; Cell cycle; Central nervous system; Chemotherapy; Coronaviruses; COVID-19; COVID-19 infection; Cytokine storm; Cytokines; Deoxyribonucleic acid; DNA; DNA damage; DNA topoisomerase (ATP-hydrolysing); Drug Design; Drug development; Drug resistance; drug therapy; Drugs; Etoposide; Growth factors; Health services; Herbal medicine; herbal medicines; Humans; Insulin; insulin-like growth factor I receptor; Lung cancer; lung neoplasms; Neoplasms - drug therapy; Podophyllotoxin; Podophyllotoxin - therapeutic use; Podophyllum; RNA; Small cell lung carcinoma; Teniposide; testes; Testicular cancer; Toxicity; Tubulin; Viral diseases