The human body burden of polychlorinated dibenzo- p -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in residents’ human milk from Guangdong Province, China
Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo- p -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-lik...
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| Published in | Toxicology research (Cambridge) Vol. 8; no. 4; pp. 552 - 559 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
01.07.2019
|
| Subjects | |
| Online Access | Get full text |
| ISSN | 2045-452X 2045-4538 |
| DOI | 10.1039/C8TX00337H |
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| Abstract | Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-
p
-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects’ resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g
−1
lipid and 2166.58 pg g
−1
lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEF
WHO 2005
) were 6.96 and 2.13 pg g
−1
lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEF
WHO 2005
) of ∑(DL-PCBs + PCDD/Fs) (8.4–9.0 pg g
−1
lipid in 2011
vs.
9.09 pg g
−1
lipid in 2018) seemed to be relatively stable during the period 2011–2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. |
|---|---|
| AbstractList | Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects' resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g-1 lipid and 2166.58 pg g-1 lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEFWHO 2005) were 6.96 and 2.13 pg g-1 lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEFWHO 2005) of ∑(DL-PCBs + PCDD/Fs) (8.4-9.0 pg g-1 lipid in 2011 vs. 9.09 pg g-1 lipid in 2018) seemed to be relatively stable during the period 2011-2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population.Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects' resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g-1 lipid and 2166.58 pg g-1 lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEFWHO 2005) were 6.96 and 2.13 pg g-1 lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEFWHO 2005) of ∑(DL-PCBs + PCDD/Fs) (8.4-9.0 pg g-1 lipid in 2011 vs. 9.09 pg g-1 lipid in 2018) seemed to be relatively stable during the period 2011-2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. Concentrations of PCDD/Fs and DL-PCBs were determined to evaluate the human body burden of dioxin-like compounds. Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo- p -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects’ resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g –1 lipid and 2166.58 pg g –1 lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEF WHO 2005 ) were 6.96 and 2.13 pg g –1 lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEF WHO 2005 ) of ∑(DL-PCBs + PCDD/Fs) (8.4–9.0 pg g –1 lipid in 2011 vs. 9.09 pg g –1 lipid in 2018) seemed to be relatively stable during the period 2011–2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo- -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects' resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g lipid and 2166.58 pg g lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEF ) were 6.96 and 2.13 pg g lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEF ) of ∑(DL-PCBs + PCDD/Fs) (8.4-9.0 pg g lipid in 2011 9.09 pg g lipid in 2018) seemed to be relatively stable during the period 2011-2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo- p -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects’ resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g −1 lipid and 2166.58 pg g −1 lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEF WHO 2005 ) were 6.96 and 2.13 pg g −1 lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEF WHO 2005 ) of ∑(DL-PCBs + PCDD/Fs) (8.4–9.0 pg g −1 lipid in 2011 vs. 9.09 pg g −1 lipid in 2018) seemed to be relatively stable during the period 2011–2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) were determined to evaluate the human body burden of dioxin-like compounds on the general population of South China. Samples were analyzed using high-resolution gas chromatography/high-resolution mass spectrometry in six pools, according to the subjects’ resident county. The mean ∑PCDD/Fs and ∑DL-PCBs concentrations in human milk samples were 323.10 pg g−1 lipid and 2166.58 pg g−1 lipid, respectively, and the corresponding WHO toxicity equivalent (TEQ) values calculated with Toxic Equivalent Factors (TEFs) established by the WHO in 2005 (TEFWHO 2005) were 6.96 and 2.13 pg g−1 lipid. The concentrations of samples collected in Guangzhou, the capital city of Guangdong Province, were higher than those taken in the other five investigation regions. The levels of PCDD/Fs and DL-PCBs in human milk and the estimated daily intake doses of breast-fed infants were still high when compared with some non-exposure areas in mainland China. TEQ levels of PCDD/Fs and DL-PCBs in the present study have been compared to data obtained from a reported national study conducted in 2011. The mean TEQ (calculated with TEFWHO 2005) of ∑(DL-PCBs + PCDD/Fs) (8.4–9.0 pg g−1 lipid in 2011 vs. 9.09 pg g−1 lipid in 2018) seemed to be relatively stable during the period 2011–2018. These findings and continuing the surveillance of PCDD/Fs and DL-PCBs in human milk will be helpful in furthering our understanding of human exposure to dioxin-like compounds in the general population. |
| Author | Huo, Weilun Jiang, Yousheng Peng, Jiewen Chen, Shaowei Zhu, Pan Huang, Rui Zhang, Jianqing Wang, Ping Chen, Zihui |
| AuthorAffiliation | c Guangdong Provincial Center for Disease Control and Prevention , No.160 Qunxian Road , Panyu District , Guangzhou , 511430 , China a Guangdong Provincial Institute of Public Health , Guangdong Provincial Center for Disease Control and Prevention , No. 160 Qunxian Road , Panyu District , Guangzhou , 511430 , China . Email: gdpiph2017@163.com ; Email: chenzh@gdiph.org.cn ; Tel: +86-020-31051176 b Department of POPs Lab , Shenzhen Center for Disease Control and Prevention , No. 8 Longyuan Road , Shenzhen , 518055 , Guangdong , China |
| AuthorAffiliation_xml | – name: a Guangdong Provincial Institute of Public Health , Guangdong Provincial Center for Disease Control and Prevention , No. 160 Qunxian Road , Panyu District , Guangzhou , 511430 , China . Email: gdpiph2017@163.com ; Email: chenzh@gdiph.org.cn ; Tel: +86-020-31051176 – name: c Guangdong Provincial Center for Disease Control and Prevention , No.160 Qunxian Road , Panyu District , Guangzhou , 511430 , China – name: b Department of POPs Lab , Shenzhen Center for Disease Control and Prevention , No. 8 Longyuan Road , Shenzhen , 518055 , Guangdong , China |
| Author_xml | – sequence: 1 givenname: Rui orcidid: 0000-0002-1546-118X surname: Huang fullname: Huang, Rui organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 2 givenname: Ping surname: Wang fullname: Wang, Ping organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 3 givenname: Jianqing surname: Zhang fullname: Zhang, Jianqing organization: Department of POPs Lab, Shenzhen Center for Disease Control and Prevention, Shenzhen, China – sequence: 4 givenname: Shaowei surname: Chen fullname: Chen, Shaowei organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 5 givenname: Pan surname: Zhu fullname: Zhu, Pan organization: Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 6 givenname: Weilun surname: Huo fullname: Huo, Weilun organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 7 givenname: Yousheng surname: Jiang fullname: Jiang, Yousheng organization: Department of POPs Lab, Shenzhen Center for Disease Control and Prevention, Shenzhen, China – sequence: 8 givenname: Zihui surname: Chen fullname: Chen, Zihui organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China – sequence: 9 givenname: Jiewen orcidid: 0000-0002-0837-6753 surname: Peng fullname: Peng, Jiewen organization: Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31341612$$D View this record in MEDLINE/PubMed |
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| Snippet | Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-
p... Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated dibenzo-... Human milk samples were collected from 179 mothers in 2017 and 2018 in six counties of Guangdong province, China. Concentrations of polychlorinated... Concentrations of PCDD/Fs and DL-PCBs were determined to evaluate the human body burden of dioxin-like compounds. Human milk samples were collected from 179... |
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| SubjectTerms | Body burden Breast milk Chemistry Dioxins Equivalence Furans Gas chromatography High resolution Human body Infants Lipids Mass spectrometry Mass spectroscopy Mathematical analysis Milk PCB Pesticides Polychlorinated biphenyls Polychlorinated dibenzodioxins Toxicity |
| Title | The human body burden of polychlorinated dibenzo- p -dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in residents’ human milk from Guangdong Province, China |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/31341612 https://www.proquest.com/docview/2249914612 https://www.proquest.com/docview/2264222538 https://pubmed.ncbi.nlm.nih.gov/PMC6610310 |
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