The role of intestinal mucosa injury induced by intra-abdominal hypertension in the development of abdominal compartment syndrome and multiple organ dysfunction syndrome

• Published in: Critical care (London, England) Vol. 17; no. 6; p. R283
• Main Authors: Cheng, Juntao, Wei, Zhiyi, Liu, Xia, Li, Ximei, Yuan, Zhiqiang, Zheng, Jiang, Chen, Xiaodong, Xiao, Guangxia, Li, Xiaoyi
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 09.12.2013; BioMed Central
• Subjects: Animals; Care and treatment; Compartment syndrome; Critically ill; Diagnosis; Disease transmission; Endotoxemia - etiology; Health aspects; Hypertension; Intestinal Mucosa - blood supply; Intestinal Mucosa - pathology; Intestinal Mucosa - physiopathology; Intra-Abdominal Hypertension - complications; Intra-Abdominal Hypertension - physiopathology; Microcirculation; Mitochondria - pathology; Multiple Organ Failure - etiology; Necrosis - etiology; Permeability; Rabbits; Risk factors; China

Abdominal distension is common in critical illness. There is a growing recognition that intra-abdominal hypertension (IAH) may complicate nonsurgical critical illness as well as after abdominal surgery. However, the pathophysiological basis of the injury to the intestinal mucosal barrier and its inf...