Enhanced and sustained biodistribution of HIV-1 neutralizing antibody VRC01LS in human genital and rectal mucosa

• Published in: Nature communications Vol. 15; no. 1; pp. 10332 - 16
• Main Authors: Lemos, Maria P., Astronomo, Rena D., Huang, Yunda, Narpala, Sandeep, Prabhakaran, Madhu, Mann, Philipp, Paez, Carmen A., Lu, Yiwen, Mize, Gregory J., Glantz, Hayley, Westerberg, Katharine, Colegrove, Hunter, Smythe, Kimberly S., Lin, Minggang, Pierce, Robert H., Hutter, Julia, Frank, Ian, Mascola, John R., McDermott, Adrian B., Bekker, Linda-Gail, McElrath, M. Juliana
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 631/250/251/1567; 631/250/2520; 631/250/347; 692/699/255/1901; 82/51; Adult; Antibodies; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - pharmacokinetics; Antibodies, Neutralizing - immunology; Biodistribution; Biological effects; Blood levels; Broadly Neutralizing Antibodies - immunology; Disease transmission; Female; Genital tract; Half-Life; HIV; HIV Antibodies - immunology; HIV Infections - immunology; HIV Infections - prevention & control; HIV Infections - virology; HIV-1 - immunology; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Immunoprophylaxis; Intestinal Mucosa - immunology; Intestinal Mucosa - metabolism; Intravenous infusion; Lamina propria; Male; Middle Aged; Monoclonal antibodies; Mucosa; Mucous Membrane - immunology; Mucous Membrane - metabolism; Mucous Membrane - virology; multidisciplinary; Neutralizing; Rectum; Rectum - virology; Science; Science (multidisciplinary); Secretions; Sexually transmitted diseases; STD; Stroma; Tissue Distribution; Tissues; Vagina - immunology; Vagina - virology; Young Adult

To prevent sexually-acquired HIV-1 infection by immunoprophylaxis, effective concentrations of broadly neutralizing antibodies are likely needed at mucosal sites of exposure. Here, we examine the biodistribution of monoclonal antibody VRC01 and its extended half-life variant, VRC01LS, in colorectal...