Interplay of human ABCC11 transporter gene variants with axillary skin microbiome functional genomics

• Published in: Scientific reports Vol. 14; no. 1; pp. 28037 - 14
• Main Authors: Stevens, Bruce R., Roesch, Luiz F. W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/181/2481; 631/326/2565/2134; 692/1807/1812; ABCC11 gene; Adult; Alleles; Anthropogenic factors; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Axilla - microbiology; Biosynthesis; DNA biosynthesis; DNA sequencing; Female; Genomics; Genomics - methods; Glutathione; Haplotypes; Humanities and Social Sciences; Humans; Male; Microbiomes; Microbiota - genetics; multidisciplinary; Mutualism; Odor; Off odor; Pedigree; Polymorphism, Single Nucleotide; Population genetics; Science; Science (multidisciplinary); Secretory vesicles; Single-nucleotide polymorphism; Skin; Skin - metabolism; Skin - microbiology

The human armpit microbiome is metabolically entangled with skin cell physiology. This “meta-organism” symbiotic mutualism results in sweat either with or without odor (osmidrosis), depending on host ABCC11 gene haplotypes. Apocrine metabolism produces odorless S-glutathione conjugate that is transf...