Site-selective chlorination of pyrrolic heterocycles by flavin dependent enzyme PrnC

• Published in: Communications chemistry Vol. 7; no. 1; p. 7
• Main Authors: Peh, GuangRong, Tay, Terence, Tan, Lee Ling, Tiong, Elaine, Bi, Jiawu, Goh, Yi Ling, Ye, Suming, Lin, Fu, Tan, Cheryl Jia Xin, Tan, Yong Zi, Wong, Joel, Zhao, Huimin, Wong, Fong Tian, Ang, Ee Lui, Lim, Yee Hwee
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/45/603; 631/535/1258/1259; 639/638/45/173; 639/638/77/603; 82; 82/80; Agrochemicals; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Chlorination; Fungicides; Halogenation; Pyrroles; Reagents; Structural analysis

Halogenation of pyrrole requires strong electrophilic reagents and often leads to undesired polyhalogenated products. Biocatalytic halogenation is a highly attractive approach given its chemoselectivity and benign reaction conditions. While there are several reports of enzymatic phenol and indole ha...