Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis - Haak, Andrew J; Kostallari, Enis; Sicard, Delphine; Ligresti, Giovanni; Choi, Kyoung Moo; Caporarello, Nunzia; Jones, Dakota L; Tan, Qi; Meridew, Jeffrey; Diaz Espinosa, Ana M; Aravamudhan, Aja; Maiers, Jessica L; et al. (Science translational medicine, 2019)
Keywords: Adaptor Proteins, Signal Transducing - antagonists & inhibitors; Adaptor Proteins, Signal Transducing - metabolism; Animals; Bleomycin; Cell Cycle Proteins - antagonists & inhibitors; Cell Cycle Proteins - metabolism; Cell Nucleus - drug effects; Cell Nucleus - metabolism; Dopa Decarboxylase - metabolism; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Female; Fibroblasts - drug effects; Fibroblasts - pathology; Gene Expression Regulation - drug effects; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - pathology; Humans; Liver Cirrhosis - pathology; Lung - drug effects; Lung - pathology; Lung Injury - pathology; Male; Mice, Inbred C57BL; Phenanthridines - pharmacology; Phenotype; Protein Transport - drug effects; Pulmonary Fibrosis - pathology; Receptors, Dopamine D1 - agonists; Receptors, Dopamine D1 - metabolism; RNA Interference; Trans-Activators - antagonists & inhibitors; Trans-Activators - metabolism; YAP-Signaling Proteins