Long-term effects of bisphosphonate therapy: perforations, microcracks and mechanical properties

• Published in: Scientific reports Vol. 7; no. 1; p. 43399
• Main Authors: Ma, Shaocheng, Goh, En Lin, Jin, Andi, Bhattacharya, Rajarshi, Boughton, Oliver R., Patel, Bhavi, Karunaratne, Angelo, Vo, Nghia T., Atwood, Robert, Cobb, Justin P., Hansen, Ulrich, Abel, Richard L.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.03.2017; Nature Publishing Group
• Subjects: 631/1647/245/1847; 631/1647/245/2221; 692/308/575; Aged; Aged, 80 and over; Alendronate - therapeutic use; Bone and Bones - diagnostic imaging; Bone and Bones - drug effects; Bone and Bones - injuries; Bone Density - drug effects; Bone Density Conservation Agents - therapeutic use; Bone Remodeling - drug effects; Case-Control Studies; Elastic Modulus; Female; Fractures, Bone - diagnostic imaging; Fractures, Bone - pathology; Fractures, Bone - surgery; Humanities and Social Sciences; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; multidisciplinary; Osteoporosis - diagnostic imaging; Osteoporosis - drug therapy; Osteoporosis - pathology; Science; Synchrotrons; Tensile Strength; X-Ray Microtomography

Osteoporosis is characterised by trabecular bone loss resulting from increased osteoclast activation and unbalanced coupling between resorption and formation, which induces a thinning of trabeculae and trabecular perforations. Bisphosphonates are the frontline therapy for osteoporosis, which act by...