Low arousal threshold is associated with altered functional connectivity of the ascending reticular activating system in patients with obstructive sleep apnea

• Published in: Scientific reports Vol. 14; no. 1; pp. 18482 - 8
• Main Authors: Byun, Jung-Ick, Jahng, Geon-Ho, Ryu, Chang-Woo, Park, Soonchan, Lee, Kun Hee, Hong, Sung Ok, Jung, Ki-Young, Shin, Won Chul
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.08.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/1647/245/1627; 631/378/3920; 692/699/375/1816; Adult; Apnea; Arousal; Arousal - physiology; Brain stem; Brain Stem - diagnostic imaging; Brain Stem - physiopathology; Case-Control Studies; Cortex (cingulate); Cortex (parietal); Female; Functional magnetic resonance imaging; Humanities and Social Sciences; Humans; Laterodorsal tegmental nucleus; Locus coeruleus; Magnetic Resonance Imaging; Male; Middle Aged; multidisciplinary; Neuroimaging; Polysomnography; Science; Science (multidisciplinary); Sleep apnea; Sleep Apnea, Obstructive - diagnostic imaging; Sleep Apnea, Obstructive - physiopathology; Sleep disorders; Ventral tegmentum

A low arousal threshold (LAT) is a pathophysiological trait of obstructive sleep apnea (OSA) that may be associated with brainstem ascending reticular activating system-cortical functional connectivity changes. We evaluated resting-state connectivity between the brainstem nuclei and 105 cortical/sub...