Inhibition of astrocytic differentiation of transplanted neural stem cells by chondroitin sulfate methacrylate hydrogels for the repair of injured spinal cord

• Published in: Biomaterials science Vol. 7; no. 5; pp. 1995 - 28
• Main Authors: Liu, Can, Fan, Lei, Xing, Jianghao, Wang, Qiyou, Lin, Chengkai, Liu, Chang, Deng, Xiaoqian, Ning, Chengyun, Zhou, Lei, Rong, Limin, Liu, Bin
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 23.04.2019
• Subjects: adverse effects; animal injuries; Animals; astrocytes; Astrocytes - cytology; Astrocytes - drug effects; axons; carcinogenesis; Cell Differentiation - drug effects; Cell Survival - drug effects; Chondroitin sulfate; Chondroitin Sulfates - chemistry; Chondroitin Sulfates - pharmacology; Differentiation; encapsulation; Female; Gene expression; gene overexpression; gene transfer; Hydrogels; Hydrogels - chemistry; hypersensitivity; Implantation; Injury analysis; Injury prevention; Methacrylates - chemistry; Neural cell transplants; neural stem cells; Neural Stem Cells - transplantation; neurogenesis; Neurogenesis - drug effects; nociception; Rats; Rats, Sprague-Dawley; Recovery; Recovery of Function - drug effects; risk; Side effects; Signs and symptoms; Spinal cord; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; sprouting; Stem cells; Surgical implants; therapeutics; Transplantation; Transplants & implants

Neural stem cell (NSC) transplantation exerts a therapeutic effect on spinal cord injury (SCI) but is limited to an unregulated differentiation pattern by which NSCs preferentially differentiate into astrocytes, with relatively few neurons. It is well established that the increased NSC-derived astro...