Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase

New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolacto...

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Published inChembiochem : a European journal of chemical biology Vol. 6; no. 4; pp. 643 - 648
Main Authors Hong, Hui, Spencer, Jonathan B, Porter, Jessica L, Leadlay, Peter F, Stinear, Tim
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.04.2005
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Acyltransferases - genetics
Acyltransferases - metabolism
Amino Acid Sequence
Bacterial Toxins - biosynthesis
Bacterial Toxins - chemistry
biosynthesis
Buruli ulcer
Lactones - chemistry
Macrolides
Mass Spectrometry
Molecular Sequence Data
Molecular Structure
Mycobacterium
Mycobacterium ulcerans
Mycobacterium ulcerans - enzymology
Mycobacterium ulcerans - genetics
Mycobacterium ulcerans - metabolism
mycolactone
Polyketide Synthases - genetics
Polyketide Synthases - metabolism
polyketides
Sequence Homology, Amino Acid
Substrate Specificity
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Abstract New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolactone polyketide synthase.
AbstractList New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolactone polyketide synthase.
Author Porter, Jessica L.
Spencer, Jonathan B.
Stinear, Tim
Hong, Hui
Leadlay, Peter F.
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Snippet New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′...
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SubjectTerms Acyltransferases - genetics
Acyltransferases - metabolism
Amino Acid Sequence
Bacterial Toxins - biosynthesis
Bacterial Toxins - chemistry
biosynthesis
Buruli ulcer
Lactones - chemistry
Macrolides
Mass Spectrometry
Molecular Sequence Data
Molecular Structure
Mycobacterium
Mycobacterium ulcerans
Mycobacterium ulcerans - enzymology
Mycobacterium ulcerans - genetics
Mycobacterium ulcerans - metabolism
mycolactone
Polyketide Synthases - genetics
Polyketide Synthases - metabolism
polyketides
Sequence Homology, Amino Acid
Substrate Specificity
Title Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fcbic.200400339
https://www.ncbi.nlm.nih.gov/pubmed/15750996
https://search.proquest.com/docview/17278855
https://search.proquest.com/docview/67735739
Volume 6
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