Synthesis of Multisubstituted Benzimidazolones via Copper-Catalyzed Oxidative Tandem C–H Aminations and Alkyl Deconstructive Carbofunctionalization

• Published in: iScience Vol. 15; pp. 127 - 135
• Main Authors: Liang, Taoyuan, Zhao, He, Gong, Lingzhen, Jiang, Huanfeng, Zhang, Min
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 31.05.2019; Elsevier
• Subjects: Catalysis; Chemistry; Organic Chemistry; Chemistry; Catalysis; Organic Chemistry
• ISSN: 2589-0042; 2589-0042
• DOI: 10.1016/j.isci.2019.04.019

Benzimidazolone constitutes the core structure of numerous pharmaceuticals, agrochemicals, inhibitors, pigments, herbicides, and fine chemicals. Amination of hydrocarbons is an attractive tool for the creation of nitrogen-containing products. However, the multiple steps, harsh conditions, and low at...