Dose-related cardiovascular effects of amrinone and epinephrine in reversing bupivacaine-induced cardiovascular depression

• Published in: Acta anaesthesiologica Scandinavica Vol. 42; no. 6; pp. 698 - 706
• Main Authors: Igarashi, T., Hirabayashi, Y., Saitoh, K., Fukuda, H., Shimizu, R., Mitsuhata, H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.07.1998; Blackwell
• Subjects: Amrinone - pharmacology; Anesthetics; Anesthetics, Local - toxicity; Animals; Biological and medical sciences; Blood Pressure - drug effects; Bupivacaine - toxicity; cardiac performance; Cardiotonic Agents - pharmacology; catecholamines: epinephrine; complications: intoxication; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Drug toxicity and drugs side effects treatment; Epinephrine - pharmacology; heart; Heart - drug effects; Heart Rate - drug effects; Hemodynamics - drug effects; local: bupivacaine; Medical sciences; Pharmacology. Drug treatments; phosphodiesterase inhibitors: amrinone; Stroke Volume - drug effects; Toxicity: cardiovascular system; Ventricular Function, Left - drug effects; volatile: sevoflurane; Agonist; Cardiotonic agent; Cardiac performance; Intravenous administration; Toxicity; Esterases; Phosphoric diester hydrolases; Amrinone; Dose activity relation; Bupivacaine; Dog; Anilide; Fissipedia; Carnivora; 3',5'-Cyclic-nucleotide phosphodiesterase; Enzyme; Enzyme inhibitor; Catecholamine; Local anesthetic; Epinephrine(drug); Vertebrata; Chemotherapy; Mammalia; Treatment; α-Adrenergic receptor; Animal; Hydrolases; Hemodynamics

Background: To ascertain the efficacy of amrinone and epinephrine in reversing bupivacaine‐induced cardiovascular depression, we investigated the time course of recovery of cardiac function with 3 doses of both agents after bupivacaine administration. Methods: In sevoflurane‐anaesthetized dogs, bupi...