Effects of eye rubbing on the levels of protease, protease activity and cytokines in tears: relevance in keratoconus

• Published in: Clinical and experimental optometry Vol. 96; no. 2; pp. 214 - 218
• Main Authors: Balasubramanian, Sivaraman A, Pye, David C, Willcox, Mark Dp
• Format: Journal Article
• Language: English
• Published: Australia Taylor & Francis 01.03.2013
• Subjects: Adult; Collagenases - analysis; cytokines; Cytokines - analysis; eye rubbing; Female; Humans; Interleukin-6 - analysis; keratoconus; Keratoconus - etiology; Keratoconus - metabolism; Male; Matrix Metalloproteinase 13 - analysis; Peptide Hydrolases - analysis; proteases; tear film; Tears - chemistry; Tumor Necrosis Factor-alpha - analysis

Proteases, protease activity and inflammatory molecules in tears have been found to be relevant in the pathogenesis of keratoconus. We sought to determine the influence of eye rubbing on protease expression, protease activity and concentration of inflammatory molecules in tears. Basal tears were col...