Tumor necrosis factor-induced ArhGEF10 selectively activates RhoB contributing to human microvascular endothelial cell tight junction disruption
Capillary endothelial cells (ECs) maintain a semi-permeable barrier between the blood and tissue by forming inter-EC tight junctions (TJs), regulating selective transport of fluid and solutes. Overwhelming inflammation, as occurs in sepsis, disrupts these TJs, leading to leakage of fluid, proteins,...
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Published in | The FASEB journal Vol. 35; no. 6; p. e21627 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2021
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Subjects | |
Online Access | Get more information |
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