Robust Vascular Protective Effect of Hydroxamic Acid Derivatives in a Sickle Mouse Model of Inflammation

• Published in: Microcirculation (New York, N.Y. 1994) Vol. 13; no. 6; pp. 489 - 497
• Main Authors: Kaul, Dhananjay K., Kollander, Rahn, Mahaseth, Hemchandra, Liu, Xiao-Du, Solovey, Anna, Belcher, John, Kelm, Robert J., Vercellotti, Gregory M., Hebbel, Robert P.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Informa UK Ltd 01.09.2006; Blackwell Publishing Ltd
• Subjects: Anemia, Sickle Cell - drug therapy; Anemia, Sickle Cell - genetics; Anemia, Sickle Cell - metabolism; Animals; anti-inflammatory; Benzamidines - administration & dosage; Blood Coagulation - drug effects; Blood Coagulation - genetics; Cell Communication - drug effects; Chronic Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelial Cells - metabolism; endothelium; Enzyme Inhibitors - administration & dosage; Humans; Hydroxamic Acids - administration & dosage; hydroxyurea; Inflammation - drug therapy; Inflammation - genetics; Inflammation - metabolism; leukocyte; Leukocytes - metabolism; Mice; Mice, Transgenic; sickle; Thromboplastin - biosynthesis; tissue factor

Objective: Clinically, the vascular pathobiology of human sickle cell disease includes an abnormal state of chronic inflammation and activation of the coagulation system. Since these biologies likely underlie development of vascular disease in sickle subjects, they offer attractive targets for novel...