Antibodies to co-trimoxazole (trimethoprim and/or sulfamethoxazole) related to the presence of the drug in a commercial low-ionic-strength solution

• Published in: Transfusion (Philadelphia, Pa.) Vol. 52; no. 4; pp. 844 - 848
• Main Authors: Pham, Bach-Nga, Gien, Dominique, Bensaad, Farid, Babinet, Jérome, Dubeaux, Isabelle, Rouger, Philippe, Pennec, Pierre-Yves Le
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.04.2012; Wiley
• Subjects: Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anti-Infective Agents - immunology; Antibodies - blood; Biological and medical sciences; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis; Blood. Blood coagulation. Reticuloendothelial system; Female; Humans; Male; Medical sciences; Middle Aged; Osmolar Concentration; Pharmacology. Drug treatments; Solutions; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Trimethoprim, Sulfamethoxazole Drug Combination - immunology; Antifolate; Sulfamethoxazole; Transfusion; Sulfonamides; Trimethoprim; Pyrimidine derivatives; Antiinfectious; Antibacterial agent; Strength

BACKGROUND: Drug‐dependent antibodies have been associated with approximately 10% of acquired immune hemolytic anemia cases. These antibodies are a rare cause of interference in pretransfusion red blood cell (RBC) serologic testing. The aim of this work was to report three cases of subjects developi...